Nazzal Zaher A, Hamdan Zakaria, Natour Nihal, Barbar Maram, Rimawi Rawan, Salaymeh Eziyeh
Department of Medicine, Faculty of Medicine and Health Sciences, An-Najah National University, Nablus 44839, State of Palestine.
Department of Nephrology, An-Najah National University Hospital, Nablus 44839, State of Palestine.
Int J Nephrol. 2021 Mar 12;2021:6684276. doi: 10.1155/2021/6684276. eCollection 2021.
The level of vitamin D status and its relationship to kidney function and liver function among patients with and without type 2 diabetes were not studied among Palestinian hemodialysis patients before. The aim of this study was to assess the status of vitamin D in hemodialysis patients with and without type 2 diabetes and its determinants.
Data were collected on 163 patients on hemodialysis therapy in the Nephrology Department at Najah National University Hospital. Information on age, sex, plasma 25 (OH)D, serum calcium, serum phosphate, parathyroid hormone, dialysis period, hypertension, diabetes, ALT, AST, albumin, alkaline phosphates, and BMI was obtained from the medical records. Data were analyzed using SPSS. . The mean level of 25 (OH)D was 17.3 ± 10.5 ng/ml. Only 12.9% of subjects had 25 (OH)D levels >30 ng/ml, whereas 65% had levels between 10 and 30 ng/ml; the remaining 22.1% were severely vitamin D deficient (<10 ng/ml). Vitamin D deficiency was more prevalent among females. It was not related to PTH, calcium, kidney, or liver function tests.
Vitamin D deficiency is highly prevalent among patients on hemodialysis with or without DM2.
此前，在巴勒斯坦血液透析患者中，尚未对2型糖尿病患者和非2型糖尿病患者的维生素D水平及其与肾功能和肝功能的关系进行研究。本研究的目的是评估2型糖尿病血液透析患者和非2型糖尿病血液透析患者的维生素D状况及其决定因素。
收集了纳贾赫国立大学医院肾内科163例接受血液透析治疗患者的数据。从病历中获取年龄、性别、血浆25(OH)D、血清钙、血清磷、甲状旁腺激素、透析时间、高血压、糖尿病、谷丙转氨酶、谷草转氨酶、白蛋白、碱性磷酸酶和体重指数等信息。使用SPSS对数据进行分析。25(OH)D的平均水平为17.3±10.5 ng/ml。只有12.9%的受试者25(OH)D水平>30 ng/ml, 而65%的受试者水平在10至30 ng/ml之间；其余22.1%严重维生素D缺乏(<10 ng/ml)。维生素D缺乏在女性中更为普遍。它与甲状旁腺激素、钙、肾脏或肝功能检查无关。
无论是否患有2型糖尿病，维生素D缺乏在血液透析患者中都非常普遍。
