Meikle A W, Stringham J D, Bishop D T, West D W
Department of Medicine, University of Utah School of Medicine, Salt Lake City 84132.
J Clin Endocrinol Metab. 1988 Jul;67(1):104-9. doi: 10.1210/jcem-67-1-104.
Both hereditary and nonhereditary factors have a decided influence on plasma sex steroid concentrations in men. We studied the relative contributions of genetic and nongenetic factors on the production rate (PR) and MCR of testosterone and dihydrotestosterone (DHT) and their conversion ratios to other metabolites in monozygotic (MZ; n = 22) and dizygotic (DZ; n = 24) male twins. Zygosity was determined by measurement of 10 blood proteins and enzymes. The kinetic studies were conducted with isotope dilution techniques. The genetic effect was determined from the equation: 2[rMZ - rDZ], where r is intraclass correlation. A heritability of over 40% was found for the PRs of DHT/body surface area and of testosterone/body surface area. Nongenetic factors accounted for 50% or more of the variation of the conversion ratios for testosterone/3 alpha-androstanediol and DHT/3 alpha-androstanediol. The results suggest that genetic factors markedly influence the PRs of testosterone and DHT, suggesting that the PR of these potent androgens is under genetic control despite the decided influence of environmental factors on their clearance.
遗传因素和非遗传因素均对男性血浆性类固醇浓度有显著影响。我们研究了遗传因素和非遗传因素对睾酮和双氢睾酮（DHT）的生成率（PR）、代谢清除率（MCR）及其向其他代谢产物的转化率的相对贡献，研究对象为同卵（MZ；n = 22）和异卵（DZ；n = 24）男性双胞胎。通过检测10种血液蛋白质和酶来确定双胞胎的合子性。采用同位素稀释技术进行动力学研究。遗传效应由公式2[rMZ - rDZ]确定，其中r为组内相关系数。发现DHT/体表面积和睾酮/体表面积的生成率遗传度超过40%。非遗传因素占睾酮/3α-雄烷二醇和DHT/3α-雄烷二醇转化率变异的50%或更多。结果表明，遗传因素显著影响睾酮和DHT的生成率，这表明尽管环境因素对这些强效雄激素的清除有显著影响，但其生成率仍受遗传控制。
