Levinson D F, Acquaviva J
Department of Psychiatry, Medical College of Pennsylvania, Philadelphia 19129.
J Clin Psychopharmacol. 1988 Jun;8(3):193-5.
Two patients experienced new onset or worsening of panic disorder during treatment with propranolol for tachycardia or palpitations associated with a diagnosis of mitral valve prolapse. Both patients had a family history of panic disorder; one also had a family history of mitral valve prolapse and depression. As antidepressant drugs can treat both depression and panic disorder, it would not be inconsistent that propranolol might exacerbate either disorder. Other possible interpretations of these two cases are discussed.
两名患者在使用普萘洛尔治疗与二尖瓣脱垂诊断相关的心动过速或心悸期间，出现了惊恐障碍的新发或加重。两名患者均有惊恐障碍家族史；其中一名患者还患有二尖瓣脱垂和抑郁症家族史。由于抗抑郁药物可以治疗抑郁症和惊恐障碍，因此普萘洛尔可能会加重这两种疾病之一并非不合理。本文讨论了这两个病例的其他可能解释。
