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可能因工业级聚植入假体硅胶臀部植入物破裂导致的鳞状细胞癌

Squamous Cell Carcinoma as a Result of Likely Industrial Grade Ruptured Poly Implant Prosthèse Silicone Buttock Implants.

作者信息

Camacho Juan P, Obaíd Miguel, Bustos Camilo, Calderón Wilfredo, Lombardi Juan J, Subiabre Rodrigo, Guler Kenneth, Correa Francisca

机构信息

Department of Plastic and Reconstructive Surgery and the Department of Pathology, Hospital del Salvador, Santiago, Chile.

出版信息

Aesthet Surg J Open Forum. 2020 Jul 6;2(3):ojaa030. doi: 10.1093/asjof/ojaa030. eCollection 2020 Sep.

Abstract

The Poly Implant Prosthèse (PIP) implants were withdrawn from the market in 2010 due to the use of a nonmedical grade silicone filler. In 2012, the French medical authorities and the International Confederation of Societies of Plastic, Reconstructive and Aesthetic Surgery recommended the extraction of PIP implants. However, during the duration of this scandal, each country in the world did not agree with a uniform procedure, and this rule was not implemented in its entirety. Although laboratory test results on PIP implants were negative for cytotoxicity and genotoxicity, there are many reports in the literature of several complications associated with PIP implants, including high rupture rates and the fact that they are 3 to 5 times more likely to produce local tissue reactions. On the other hand, the development of more strange and worse prognosis complications, such as the development of squamous carcinoma associated with the use of silicone implants (not necessarily related to PIP implants), is less known. To date, only 6 cases have been reported, and all are related to breast augmentation. The authors made the first report of primary gluteal squamous cell cancer related to rupture and delayed removal of PIP silicone buttock implants.

摘要

聚植入假体(PIP)由于使用了非医用级硅胶填充物,于2010年退出市场。2012年,法国医疗当局以及国际整形、重建与美容外科学会联合会建议取出PIP植入物。然而,在这起丑闻期间,世界上每个国家对于统一程序并未达成一致,该规定也未完全实施。尽管关于PIP植入物的实验室检测结果显示细胞毒性和基因毒性均为阴性,但文献中有许多关于PIP植入物相关并发症的报道,包括高破裂率以及它们产生局部组织反应的可能性是其他植入物的3至5倍。另一方面,更罕见且预后更差的并发症的发生,比如与硅胶植入物使用相关的鳞状细胞癌的发生(不一定与PIP植入物有关),则鲜为人知。迄今为止,仅报道过6例,且均与隆胸有关。作者首次报告了与PIP硅胶臀部植入物破裂及取出延迟相关的原发性臀鳞状细胞癌。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/38cd/7671286/12264d670208/ojaa030f0001.jpg

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