Lee Ling-Ling
PhD, RN, Associate Professor, Department of Nursing, College of Nursing, Tzu Chi University of Science and Technology, Taiwan, ROC.
Hu Li Za Zhi. 2021 Apr;68(2):85-91. doi: 10.6224/JN.202104_68(2).11.
The Cochrane risk of bias (RoB) tool is used widely in systematic review studies and evidence-based healthcare. However, how this tool is used and how domains and signaling questions are interpreted may vary significantly across studies. This article was written to illustrate the limitations of the Risk of Bias tool version 1, which have been addressed in the new version of this tool, Risk of Bias version 2 (RoB 2). In addition to introducing the five domains (including risk of bias due to the randomization process, deviations from the intended interventions, missing outcome data, measurement of the outcome, and selection of reported results) and the assessment of overall bias risk, the procedure of using the RoB 2 tool to assess randomized controlled trials when conducting a systematic review study and evidence-based practice is also introduced. The structure of pre-, during-, and post-assessment is used in this article to describe clearly the procedure of bias assessment. An overall introduction to the relevant resources related to RoB 2 (such as guidance, software, and websites) is also addressed, to further enhance the familiarity with RoB 2 of nursing staffs and systematic review researchers and to increase their ability to use this tool effectively.
Cochrane偏倚风险（RoB）工具在系统评价研究和循证医疗中被广泛使用。然而，该工具的使用方式以及各领域和信号问题的解释在不同研究中可能存在显著差异。本文旨在阐述偏倚风险工具第1版的局限性，这些局限性在该工具的新版本——偏倚风险第2版（RoB 2）中已得到解决。除了介绍五个领域（包括随机化过程导致的偏倚风险、与预期干预的偏离、结局数据缺失、结局测量以及报告结果的选择）和整体偏倚风险评估外，还介绍了在进行系统评价研究和循证实践时使用RoB 2工具评估随机对照试验的程序。本文采用评估前、评估期间和评估后的结构来清晰描述偏倚评估程序。此外，还对与RoB 2相关的资源（如指南、软件和网站）进行了全面介绍，以进一步提高护理人员和系统评价研究人员对RoB 2的熟悉程度，并增强他们有效使用该工具的能力。
