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经阴道尿道肉切开术治疗先天性巨尿道下梗阻胎儿下尿路梗阻。

Fetoscopic urethral meatotomy in fetuses with lower urinary tract obstruction by congenital megalourethra.

机构信息

Prenatal Diagnosis and Fetal Surgery Center, Medicina Fetal México and Fetal Medicine Foundation of Mexico, Queretaro, México.

Instituto de Ciencias de la Salud (ICSa), Universidad Autónoma del Estado de Hidalgo (UAEH), Hidalgo, México.

出版信息

Prenat Diagn. 2021 May;41(6):772-777. doi: 10.1002/pd.5946. Epub 2021 Apr 13.

Abstract

BACKGROUND

To describe the perinatal outcomes of fetoscopic urethral meatotomy (FUM) in fetuses with lower urinary tract obstruction (LUTO) by congenital megalourethra.

STUDY DESIGN

Between 2012 and 2020, 226 cases with LUTO were referred to our fetal surgery center in Queretaro, Mexico. We report the perinatal outcome of cases with LUTO by congenital megalourethra that were selected for FUM in an attempt to release the penile urethral obstruction.

RESULTS

Congenital megalourethra was diagnosed in 10 cases (4.4%) but only 3 cases (30%) with obstructive megalourethra and megacystis were selected for fetal surgery. Fetoscopic urethral metatotomy was successfully performed in all three cases at a median gestational age (GA) of 21.4 (18.0-26.7) weeks and with a median surgical time of 27 (12-43) min. A resolution of urethral dilatation and subsequent reduction of the penile length and normalization of both the bladder size and amniotic fluid were observed in all cases. The median GA at delivery was 35.2 (range: 30.6-38.0) weeks. There were no fetal deaths but one neonatal death (33%) secondary to renal failure and preterm delivery.

CONCLUSION

In fetuses with LUTO by congenital obstructive megalourethra, FUM is feasible and is associated with good perinatal outcomes.

摘要

背景

描述先天性巨尿道症导致的下尿路梗阻(LUTO)胎儿行经阴道腔内尿道切开术(FUM)的围产结局。

研究设计

2012 年至 2020 年期间,共有 226 例 LUTO 胎儿转诊至墨西哥克雷塔罗的胎儿外科中心。我们报告了先天性巨尿道症导致的 LUTO 病例的围产结局,这些病例选择行 FUM 以尝试解除阴茎尿道梗阻。

结果

先天性巨尿道症诊断出 10 例(4.4%),但只有 3 例(30%)伴有梗阻性巨尿道症和巨膀胱的病例被选择行胎儿手术。所有 3 例病例均在中位孕龄(GA)为 21.4(18.0-26.7)周时成功施行经阴道腔内尿道切开术,中位手术时间为 27(12-43)min。所有病例均观察到尿道扩张得到缓解,随后阴茎长度缩短,膀胱大小和羊水均恢复正常。中位分娩 GA 为 35.2(范围:30.6-38.0)周。无胎儿死亡,但有 1 例新生儿死亡(33%),原因是肾衰竭和早产。

结论

对于先天性梗阻性巨尿道症导致的 LUTO 胎儿,FUM 是可行的,并且具有良好的围产结局。

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