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接受辅助性腹膜透析的患者表现出更好的技术生存率:竞争风险分析。

Patients undergoing assisted peritoneal dialysis to show a better technique survival: A competing risk analysis.

机构信息

Department of Nursing, Second Affiliated Hospital of Soochow University, Suzhou, China.

Department of Nephrology, Second Affiliated Hospital of Soochow University, Suzhou, China.

出版信息

Int J Clin Pract. 2021 Jul;75(7):e14192. doi: 10.1111/ijcp.14192. Epub 2021 Apr 23.

DOI:10.1111/ijcp.14192
PMID:33792114
Abstract

AIMS

To compare patient mortality and technique survival between patients undergoing assisted peritoneal dialysis (aPD) and self-care peritoneal dialysis (sPD).

METHODS

Patients who underwent peritoneal dialysis (PD) at the dialysis center of Second Affiliated Hospital of Soochow University from January 1, 2012 to December 31, 2016, were included and followed to December 31, 2019. Subjects were divided into aPD and sPD groups according to whether the patient could independently complete the PD procedure. Differences in mortality and technique failure rates were compared using competing risk analysis.

RESULTS

A total of 384 patients were included in this study, with 274 patients in the sPD group and 110 patients in the aPD group. The multivariate competing risk regression analysis revealed that age (HR 1.03,95%CI 1.01-1.05, P < .001), aPD (HR 1.84,95%CI 1.10-3.08, P = .02), diabetes (HR 1.51, 95%CI 1.00-2.30, P = .05), residual renal function (HR 0.89, 95%CI 0.82-0.97, P = .005) and serum albumin level (HR 0.92, 95% CI 0.89-0.96, P < .001) were the independent risk factors for mortality. Besides, technique failure in aPD patients was lower than in the sPD group (HR 0.85, 95% CI 0.68-0.97, P = .03).

CONCLUSION

These results found that aPD patients had higher mortality rates but lower technique failure rates than sPD patients. Higher mortality in aPD is probably related to the negative selection of the more comorbid patients. ​ ​.

摘要

目的

比较辅助腹膜透析(aPD)和自我护理腹膜透析(sPD)患者的死亡率和技术生存率。

方法

纳入 2012 年 1 月 1 日至 2016 年 12 月 31 日在苏州大学第二附属医院透析中心行腹膜透析的患者,并随访至 2019 年 12 月 31 日。根据患者是否能独立完成 PD 操作,将患者分为 aPD 和 sPD 组。采用竞争风险分析比较死亡率和技术失败率的差异。

结果

本研究共纳入 384 例患者,其中 sPD 组 274 例,aPD 组 110 例。多变量竞争风险回归分析显示,年龄(HR 1.03,95%CI 1.01-1.05,P<0.001)、aPD(HR 1.84,95%CI 1.10-3.08,P=0.02)、糖尿病(HR 1.51,95%CI 1.00-2.30,P=0.05)、残余肾功能(HR 0.89,95%CI 0.82-0.97,P=0.005)和血清白蛋白水平(HR 0.92,95%CI 0.89-0.96,P<0.001)是死亡率的独立危险因素。此外,aPD 患者的技术失败率低于 sPD 组(HR 0.85,95%CI 0.68-0.97,P=0.03)。

结论

这些结果表明,aPD 患者的死亡率高于 sPD 患者,但技术失败率较低。aPD 患者死亡率较高可能与合并症较多的患者的负面选择有关。

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