社区人群认知障碍的早期预防：北京老龄化脑健康促进计划。

Early prevention of cognitive impairment in the community population: The Beijing Aging Brain Rejuvenation Initiative.

机构信息

State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China.

Institute of Basic Research in Clinical Medicine, China Academy of Traditional Chinese Medicine, Beijing, China.

出版信息

Alzheimers Dement. 2021 Oct;17(10):1610-1618. doi: 10.1002/alz.12326. Epub 2021 Mar 31.

DOI:10.1002/alz.12326

PMID:33792187

Abstract

Facing considerable challenges associated with aging and dementia, China urgently needs an evidence-based health-care system for prevention and management of dementia. The Beijing Aging Brain Rejuvenation Initiative (BABRI) is a community-based cohort study initiated in 2008 that focuses on asymptomatic stages of dementia, aims to develop community-based prevention strategies for cognitive impairment, and provides a platform for scientific research and clinical trials. Thus far, BABRI has recruited 10,255 participants (aged 50 and over, 60.3% female), 2021 of whom have been followed up at least once at a 2- or 3-year interval. This article presents aims and study design of BABRI; summarizes preliminary behavioral and neuroimaging findings on mild cognitive impairment (MCI) and results of clinical trials on MCI; and discusses issues concerning early prevention in community, MCI diagnosis methods, and applications of database of aging and dementia. BABRI is proposed to build a systematic framework on brain health in old age.

摘要

面对与老龄化和痴呆相关的巨大挑战，中国迫切需要建立一个基于证据的痴呆症预防和管理医疗体系。北京老龄化脑健康研究计划（BABRI）是一个 2008 年启动的社区为基础的队列研究，专注于痴呆症的无症状阶段，旨在制定基于社区的认知障碍预防策略，并为科学研究和临床试验提供平台。到目前为止，BABRI 已经招募了 10255 名参与者（年龄在 50 岁及以上，60.3%为女性），其中 2021 名参与者至少每隔 2-3 年接受了一次随访。本文介绍了 BABRI 的目标和研究设计；总结了轻度认知障碍（MCI）的初步行为和神经影像学发现以及 MCI 临床试验的结果；并讨论了社区早期预防、MCI 诊断方法以及老龄化和痴呆数据库应用等问题。BABRI 旨在构建一个老年脑健康的系统框架。