Comment on "Combining brentuximab vedotin with dexamethasone, high-dose cytarabine and cisplatin as salvage treatment in relapsed or refractory Hodgkin lymphoma: the phase II HOVON/LLPC Transplant BRaVE study.".
作者信息
Picardi Marco, Giordano Claudia
机构信息
Department of Clinical Medicine and Surgery, Hematology Unit, Federico II University Medical School, Naples.
出版信息
Haematologica. 2021 Apr 1;106(4):1226-1227. doi: 10.3324/haematol.2020.278203.
Abstract
摘要
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Comment on "Combining brentuximab vedotin with dexamethasone, high-dose cytarabine and cisplatin as salvage treatment in relapsed or refractory Hodgkin lymphoma: the phase II HOVON/LLPC Transplant BRaVE study.".对“将本妥昔单抗与地塞米松、大剂量阿糖胞苷和顺铂联合用于复发或难治性霍奇金淋巴瘤的挽救治疗：II期HOVON/LLPC移植BRAVE研究”的评论。
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Phase I dose-escalation study of brentuximab-vedotin combined with dexamethasone, high-dose cytarabine and cisplatin, as salvage treatment in relapsed/refractory classical Hodgkin lymphoma: The HOVON/LLPC Transplant BRaVE study.本妥昔单抗联合地塞米松、大剂量阿糖胞苷和顺铂作为复发/难治性经典型霍奇金淋巴瘤挽救治疗的Ⅰ期剂量递增研究：HOVON/LLPC移植BRAVE研究
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Pembrolizumab monotherapy in patients with primary refractory classical hodgkin lymphoma who relapsed after salvage autologous stem cell transplantation and/or brentuximab vedotin therapy: KEYNOTE-087 subgroup analysis.帕博利珠单抗单药治疗在接受挽救性自体干细胞移植和/或维布妥昔单抗治疗后复发的原发性难治性经典型霍奇金淋巴瘤患者中的应用：KEYNOTE-087亚组分析
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Five-year survival and durability results of brentuximab vedotin in patients with relapsed or refractory Hodgkin lymphoma.复发或难治性霍奇金淋巴瘤患者使用维布妥昔单抗的5年生存率和疗效持久性结果
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Brentuximab vedotin plus bendamustine versus platinum-based regimens as 1st salvage therapy and 'bridge' to autologous hematopoietic stem cell transplantation for relapsed/refractory Hodgkin lymphoma.与铂类方案相比，本妥昔单抗联合苯达莫司汀作为复发/难治性霍奇金淋巴瘤一线挽救治疗及自体造血干细胞移植“桥梁”的疗效对比
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Biol Blood Marrow Transplant. 2015 Dec;21(12):2136-2140. doi: 10.1016/j.bbmt.2015.07.018. Epub 2015 Jul 26.
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Bendamustine supercharge plus brentuximab vedotin as early salvage therapy following failure to obtain complete metabolic remission after two cycles of adriamycin-bleomycin-vinblastine-dacarbazine for classic Hodgkin lymphoma in patients aged ≤ 60 years: Long-term efficacy results of a retrospective multicentre study.对于年龄≤60岁的经典型霍奇金淋巴瘤患者，在接受两个周期的阿霉素-博来霉素-长春花碱-达卡巴嗪治疗后未获得完全代谢缓解时，苯达莫司汀强化联合 Brentuximab vedotin 作为早期挽救治疗：一项回顾性多中心研究的长期疗效结果。
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本文引用的文献
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Hodgkin lymphoma: outsmarting HRS cells.霍奇金淋巴瘤：智胜霍奇金和里德-斯腾伯格细胞。
Blood. 2020 Nov 19;136(21):2362-2364. doi: 10.1182/blood.2020008250.
2
Combining brentuximab vedotin with dexamethasone, high-dose cytarabine and cisplatin as salvage treatment in relapsed or refractory Hodgkin lymphoma: the phase II HOVON/LLPC Transplant BRaVE study.在复发或难治性霍奇金淋巴瘤中，将 Brentuximab vedotin 与地塞米松、高剂量阿糖胞苷和顺铂联合作为挽救治疗：HOVON/LLPC 移植 BRaVE 研究的 II 期研究。
Haematologica. 2021 Apr 1;106(4):1129-1137. doi: 10.3324/haematol.2019.243238.
3
Gemcitabine and bendamustine is a safe and effective salvage regimen for patients with recurrent/refractory Hodgkin lymphoma: Results of a phase 1/2 study.吉西他滨和苯达莫司汀是复发性/难治性霍奇金淋巴瘤患者安全有效的挽救方案：一项 1/2 期研究的结果。
Cancer. 2020 Mar 15;126(6):1235-1242. doi: 10.1002/cncr.32640. Epub 2019 Dec 10.
4
Brentuximab vedotin followed by bendamustine supercharge for refractory or relapsed Hodgkin lymphoma.Brentuximab vedotin 序贯泊马度胺超剂量治疗难治或复发霍奇金淋巴瘤。
Blood Adv. 2019 May 14;3(9):1546-1552. doi: 10.1182/bloodadvances.2019000123.
5
Brentuximab vedotin and ESHAP is highly effective as second-line therapy for Hodgkin lymphoma patients (long-term results of a trial by the Spanish GELTAMO Group).本妥昔单抗维布妥昔单抗和ESHAP 作为二线治疗霍奇金淋巴瘤患者非常有效（西班牙 GELTAMO 组试验的长期结果）。
Ann Oncol. 2019 Apr 1;30(4):612-620. doi: 10.1093/annonc/mdz009.
6
Brentuximab vedotin plus bendamustine: a highly active first salvage regimen for relapsed or refractory Hodgkin lymphoma.本妥昔单抗维迪西妥单抗联合苯达莫司汀：复发或难治性霍奇金淋巴瘤的高效一线挽救治疗方案。
Blood. 2018 Jul 5;132(1):40-48. doi: 10.1182/blood-2017-11-815183. Epub 2018 Apr 27.
7
PET-adapted sequential salvage therapy with brentuximab vedotin followed by augmented ifosamide, carboplatin, and etoposide for patients with relapsed and refractory Hodgkin's lymphoma: a non-randomised, open-label, single-centre, phase 2 study.PET 适应序贯挽救治疗，采用 Brentuximab Vedotin 继以增强异环磷酰胺、卡铂和依托泊苷，用于复发和难治性霍奇金淋巴瘤患者：一项非随机、开放标签、单中心、2 期研究。
Lancet Oncol. 2015 Mar;16(3):284-92. doi: 10.1016/S1470-2045(15)70013-6. Epub 2015 Feb 13.
8
Brentuximab vedotin (SGN-35) for relapsed CD30-positive lymphomas.本妥昔单抗维迪昔（SGN-35）治疗复发性 CD30 阳性淋巴瘤。
N Engl J Med. 2010 Nov 4;363(19):1812-21. doi: 10.1056/NEJMoa1002965.
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