铜催化的炔基溴化物和末端炔烃的全氟烷基化反应
Copper-Catalyzed Perfluoroalkylation of Alkynyl Bromides and Terminal Alkynes.
作者信息
Fan Shilu, Zheng Chenggong, Zheng Kaiting, Li Junlan, Liu Yaomei, Yan Fangpei, Xiao Hua, Feng Yi-Si, Zhu Yuan-Yuan
机构信息
School of Chemistry and Chemical Engineering, Hefei University of Technology, 193 Tunxi Road, Anhui 230000, China.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China.
出版信息
Org Lett. 2021 Apr 16;23(8):3190-3194. doi: 10.1021/acs.orglett.1c00906. Epub 2021 Apr 1.
A copper-catalyzed one-pot perfluoroalkylation of alkynyl bromides and terminal alkynes has been disclosed, and the corresponding perfluoroalkylated alkynes could be attained in good to excellent yields. The new straightforward transformation shows high efficiency (0.01-0.5 mol % catalyst loading), broad substrate scope, and remarkable functional group tolerance and provides a facile approach for useful application in life and material sciences.
已公开了一种铜催化的炔基溴化物和末端炔烃的一锅法全氟烷基化反应，相应的全氟烷基化炔烃能够以良好至优异的产率得到。这种新的直接转化反应具有高效性（催化剂负载量为0.01 - 0.5 mol%）、广泛的底物范围和出色的官能团耐受性，并为在生命科学和材料科学中的实际应用提供了一种简便方法。
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