Liu Feng, Wu Na, Cheng Xu
Institute of Chemistry and Biomedical Sciences, Jiangsu Key Laboratory of Advanced Organic Materials, National Demonstration Center for Experimental Chemistry Education, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China.
State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, China.
Org Lett. 2021 Apr 16;23(8):3015-3020. doi: 10.1021/acs.orglett.1c00704. Epub 2021 Apr 1.
Chlorination with chlorine is straightforward, highly reactive, and versatile, but it has significant limitations. In this Letter, we introduce a protocol that could combine the efficiency of electrochemical transformation and the high reactivity of chlorine. By utilizing ClCCN as the chloride source, donating up to all three chloride atom, the reaction could generate and consume the chlorine on demand to achieve the chlorination of aromatic compounds and electrodeficient alkenes.
用氯气进行氯化反应简单直接、反应活性高且用途广泛，但它也有显著的局限性。在本信函中，我们介绍了一种可将电化学转化效率与氯的高反应活性相结合的方法。通过使用ClCCN作为氯源，最多可提供全部三个氯原子，该反应能够按需生成并消耗氯，以实现芳香族化合物和缺电子烯烃的氯化反应。
