Hummel M, Lhoste F, Tillement J P
Arch Fr Pediatr. 1977 Aug-Sep;34(7):671-83.
The indications for the administration of cardiotonic heterosides are quite similar in adults and children. However, their use in children raises several practical problems, generally related to differences in kinetics and/or tissular sensitivity. The pharmacodynamic properties and the kinetics of cardiotonic glycosides of digitalis are reviewed and therapeutic and toxicologic effects are discussed.
强心苷类药物在成人和儿童中的应用指征颇为相似。然而,它们在儿童中的使用引发了一些实际问题,这些问题通常与动力学和/或组织敏感性差异有关。本文对洋地黄强心苷类药物的药效学特性和动力学进行了综述,并探讨了其治疗作用和毒理学效应。