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肠道的神经内分泌肽及其在食物摄入调节中的作用。

Neuroendocrine Peptides of the Gut and Their Role in the Regulation of Food Intake.

机构信息

Charité Center for Internal Medicine and Dermatology, Department for Psychosomatic Medicine, Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, Berlin Institute of Health, Berlin, Germany.

Vatche and Tamar Manoukian Division of Digestive Diseases, Department of Medicine, CURE: Digestive Diseases Research Center, David Geffen School of Medicine, UCLA, Los Angeles, California, USA.

出版信息

Compr Physiol. 2021 Apr 1;11(2):1679-1730. doi: 10.1002/cphy.c200007.

DOI:10.1002/cphy.c200007
PMID:33792904
Abstract

The regulation of food intake encompasses complex interplays between the gut and the brain. Among them, the gastrointestinal tract releases different peptides that communicate the metabolic state to specific nuclei in the hindbrain and the hypothalamus. The present overview gives emphasis on seven peptides that are produced by and secreted from specialized enteroendocrine cells along the gastrointestinal tract in relation with the nutritional status. These established modulators of feeding are ghrelin and nesfatin-1 secreted from gastric X/A-like cells, cholecystokinin (CCK) secreted from duodenal I-cells, glucagon-like peptide 1 (GLP-1), oxyntomodulin, and peptide YY (PYY) secreted from intestinal L-cells and uroguanylin (UGN) released from enterochromaffin (EC) cells. © 2021 American Physiological Society. Compr Physiol 11:1679-1730, 2021.

摘要

摄食调节包括肠道和大脑之间的复杂相互作用。其中，胃肠道释放不同的肽，将代谢状态传递给后脑和下丘脑的特定核。本综述重点介绍了七种由胃肠道中特定的肠内分泌细胞产生和分泌的肽，这些肽与营养状态有关。这些已确立的摄食调节剂包括胃泌素和来自胃 X/A 样细胞的 nesfatin-1、来自十二指肠 I 细胞的胆囊收缩素 (CCK)、来自肠道 L 细胞的胰高血糖素样肽 1 (GLP-1)、胃饥饿素、肽 YY (PYY) 和来自肠嗜铬细胞 (EC) 细胞的尿鸟苷素 (UGN)。 2021 年美国生理学会。综合生理学 11:1679-1730,2021.

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Neuroendocrine Peptides of the Gut and Their Role in the Regulation of Food Intake.

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[2]
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[3]
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