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“有死亡意愿”与晚年的心血管死亡率独立相关。来自 TILDA 的数据。

'Wish to die' is independently associated with cardiovascular mortality in later life. Data from TILDA.

机构信息

Mercers Institute for Successful Ageing, St James's Hospital, Dublin, Ireland.

The Irish Longitudinal Study on Ageing, Trinity College Dublin, Dublin, Ireland.

出版信息

Int J Geriatr Psychiatry. 2021 Jul;36(7):1004-1010. doi: 10.1002/gps.5550. Epub 2021 May 7.

Abstract

BACKGROUND

There is an established bidirectional relationship between mental and heart health in later life but the link between wish to die (WTD) and cardiovascular mortality is less well-defined.

METHODS

This is a longitudinal study examining the association between WTD and mortality over 9-year follow-up in a large population-representative sample of older adults. Individual-level survey data was linked to official death registration data, divided into cardiovascular and noncardiovascular causes. WTD was defined as answering affirmatively when asked 'In the last month, have you felt that you would rather be dead?' Regression models were used to obtain hazard ratios for the association between WTD at Wave 1 and mortality. Kaplan-Meier plots were used to compare survival across groups.

RESULTS

Just over 3% (275/8124) of participants reported WTD. Mortality data was available for 9% of participants (755/8124). WTD was significantly associated with all-cause mortality, with a hazard ratio of 1.41 (95% confidence interval [CI]: 1.00-1.99). Findings were attenuated and no longer significant after excluding participants with heart disease or depression/anxiety/other psychiatric illness. WTD was significantly associated with cardiovascular mortality (hazard ratio: 2.14 [95% CI: 1.21-3.78]), even after excluding participants with depression/anxiety/other illnesses but not heart disease. WTD was not associated with an increased risk of death due to non-cardiovascular causes.

CONCLUSIONS

Older people who report a wish to die have double the risk of death from cardiovascular disease in the following 9 years, even when those with depression, anxiety or other mental health problems are excluded.

摘要

背景

心理健康和心脏健康在晚年存在着既定的双向关系,但愿望死亡(WTD)与心血管死亡率之间的联系还不太明确。

方法

这是一项纵向研究,在一个大型的老年人群代表性样本中,在 9 年的随访期间,检查了 WTD 与死亡率之间的关联。将个体水平的调查数据与官方死亡登记数据相关联,分为心血管和非心血管原因。WTD 的定义是当被问及“在上个月,你是否曾觉得自己宁愿死?”时回答肯定。使用回归模型获得 WTD 在第 1 波与死亡率之间关联的风险比。使用 Kaplan-Meier 图比较各组的生存情况。

结果

略多于 3%(275/8124)的参与者报告了 WTD。只有 9%的参与者(755/8124)有死亡率数据。WTD 与全因死亡率显著相关,风险比为 1.41(95%置信区间 [CI]:1.00-1.99)。排除患有心脏病或抑郁症/焦虑症/其他精神疾病的参与者后,结果减弱且不再显著。WTD 与心血管死亡率显著相关(风险比:2.14 [95% CI:1.21-3.78]),即使排除了患有抑郁症/焦虑症/其他疾病但没有心脏病的参与者也是如此。WTD 与非心血管原因导致的死亡风险增加无关。

结论

报告有死亡愿望的老年人在接下来的 9 年内死于心血管疾病的风险增加一倍,即使排除了患有抑郁症、焦虑症或其他精神健康问题的患者也是如此。

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