Department of Physical Medicine and Rehabilitation, Cukurova University Faculty of Medicine, Adana, Turkey.
Department of Clinical Immunology and Rheumatology, Sanjay Gandhi Postgraduate Institute of Medical Sciences, Lucknow, India.
Int J Rheum Dis. 2021 Jul;24(7):896-903. doi: 10.1111/1756-185X.14104. Epub 2021 Apr 1.
Idiopathic inflammatory myopathy (IIM) is a term used for a heterogeneous group of diseases characterized by severe muscle weakness. In addition to pharmacological treatment options, non-pharmacological methods such as exercising are essential for proper management of myositis. The present article aimed to provide an insight into the potential pathophysiological mechanisms underlying exercise-related benefits in myositis. A systematic search was performed on PubMed/MEDLINE, Scopus, Web of Science, and Google Scholar using the following keywords and their combinations: "idiopathic inflammatory myopathy", "inflammatory myopathy", "myositis", "polymyositis", "dermatomyositis", "inclusion body myositis", and "exercise". Current literature indicates that exercising has impact on both immune and non-immune pathways in patients with IIM. Exercise-related benefits include (a) increased mitochondrial biogenesis/enzyme activity, (b) reconditioning of immune/inflammatory pathways, (c) decreased endoplasmic reticulum stress, (d) modulation of gene expression, (e) increased protein synthesis and cytoskeletal remodeling, and (f) decreased muscle fibrosis and non-muscle area infiltrates. With its certain benefits, exercise stands as a precious non-pharmacological treatment option for patients with IIM.
特发性炎性肌病（IIM）是一组异质性疾病的术语，其特征为严重的肌肉无力。除了药物治疗选择外，非药物方法，如锻炼，对于肌炎的适当管理也是必不可少的。本文旨在深入了解与锻炼相关的益处背后潜在的病理生理机制。我们在 PubMed/MEDLINE、Scopus、Web of Science 和 Google Scholar 上使用以下关键词及其组合进行了系统搜索：“特发性炎性肌病”、“炎性肌病”、“肌炎”、“多发性肌炎”、“皮肌炎”、“包涵体肌炎”和“锻炼”。目前的文献表明，锻炼对 IIM 患者的免疫和非免疫途径都有影响。与锻炼相关的益处包括：（a）增加线粒体生物发生/酶活性；（b）重新调节免疫/炎症途径；（c）减少内质网应激；（d）调节基因表达；（e）增加蛋白质合成和细胞骨架重塑；（f）减少肌肉纤维化和非肌肉区域浸润。锻炼具有一定的益处，是 IIM 患者宝贵的非药物治疗选择。
