眼蠕形螨感染的睑板腺功能障碍患者的活体共聚焦显微镜检查。
In Vivo Confocal Microscopy in Blepharitis Patients with Ocular Demodex Infestation.
机构信息
Department of Ophthalmology, Koç University School of Medicine, Istanbul, Turkey.
Cerrahpasa Medical Faculty, Department of Ophthalmology, Istanbul University-Cerrahpasa, Istanbul, Turkey.
出版信息
Ocul Immunol Inflamm. 2022 Aug;30(6):1378-1383. doi: 10.1080/09273948.2021.1875006. Epub 2021 Apr 1.
PURPOSE
To compare corneal in-vivo confocal microscopy (IVCM) findings in patients with seborrheic blepharitis with healthy controls and to evaluate the correlation with the load.
METHODS
Sixty-two positive seborrheic blepharitis patients and 24 controls were included. Four eyelashes from each eye were examined. The median value of count (5 mites/eye) was assigned as the cutoff value to create low and high infestation subgroups. Corneal nerve parameters (fiber length;CNFL, fiber density;CNFD, branch length;CNBL, branch density;CNBD) and dendritic cell density (DCD) were analyzed by IVCM for all participants.
RESULTS
The mean DCD of eyes in low (37.62 ± 25.18 cells/mm) and high (76.00 ± 44.00 cells/mm) load groups were significantly higher than those in the control group (14.25 ± 2.68 cells/mm) ( < .001). CNFL, CNFD, CNBL and CNBD were significantly lower in low and high groups compared to controls ( < .001).
CONCLUSIONS
positive seborrheic blepharitis patients showed significantly reduced density of corneal nerves and elevated DCD levels.
目的
比较脂溢性睑缘炎患者与健康对照者的活体共焦显微镜（IVCM）角膜检查结果，并评估其与蠕形螨负荷的相关性。
方法
纳入 62 例阳性脂溢性睑缘炎患者和 24 例对照者。每只眼的 4 根睫毛进行检查。以 5 只螨虫/眼的中位数作为截断值，创建低和高螨感染亚组。对所有参与者进行 IVCM 分析角膜神经参数（纤维长度；CNFL、纤维密度；CNFD、分支长度；CNBL、分支密度；CNBD）和树突状细胞密度（DCD）。
结果
低（37.62 ± 25.18 个细胞/mm）和高（76.00 ± 44.00 个细胞/mm）负荷组的眼 DCD 均值明显高于对照组（14.25 ± 2.68 个细胞/mm）（<.001）。与对照组相比，低和高 组的 CNFL、CNFD、CNBL 和 CNBD 明显降低（<.001）。
结论
阳性脂溢性睑缘炎患者的角膜神经密度显著降低，DCD 水平升高。
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