内质网氨肽酶 1 基因多态性与中国人群子痫前期的关联研究。
Association study of polymorphisms of endoplasmic reticulum aminopeptidase 1 gene with preeclampsia in Chinese populations.
机构信息
Department of Obstetrics, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China.
出版信息
Clin Exp Hypertens. 2021 Aug 18;43(6):550-554. doi: 10.1080/10641963.2021.1907400. Epub 2021 Apr 2.
OBJECTIVE
To explore the correlation of polymorphisms of endoplasmic reticulum aminopeptidase-1 (ERAP-1) gene in Chinese women with preeclampsia.
METHOD
In this case-control study, 51 severely preeclamptic and 48 healthy pregnant women were retrospectively involved in Beijing Obstetrics and Gynecology Hospital from October 2017 to October 2019. The venous blood and umbilical cord blood were collected to analyze different single nucleotide polymorphisms (SNPs) in ERAP-1 gene in both groups.
RESULT
We firstly screened nine SNPs that were significantly different between two groups (< .1) via univariate analysis. Pearson Chi-Square Test and Fisher's Exact Test were performed to verify the correlation of SNPs with preeclampsia. Finally, genotype TC located in 96121524 position was associated with an increased risk of preeclampsia (= .020, OR = 2.002, 95% CI: 0.687-5.831).
CONCLUSION
There might be a correlation between polymorphism of 96121524 in ERAP-1 gene and preeclampsia susceptibility in pregnant women of Han nationality in Beijing.
目的
探讨内质网氨肽酶-1（ERAP-1）基因多态性与中国汉族女性子痫前期的相关性。
方法
本病例对照研究回顾性纳入了 2017 年 10 月至 2019 年 10 月期间在北京妇产医院就诊的 51 例重度子痫前期患者和 48 例健康孕妇。采集静脉血和脐静脉血，分析两组 ERAP-1 基因的不同单核苷酸多态性（SNP）。
结果
通过单因素分析，我们首先筛选出两组间存在显著差异的 9 个 SNP（<0.1）。采用 Pearson 卡方检验和 Fisher 确切概率法验证 SNP 与子痫前期的相关性。最终，位于 96121524 位的 TC 基因型与子痫前期的发生风险增加相关（=0.020，OR=2.002，95%CI：0.687-5.831）。
结论
在北京汉族孕妇中，ERAP-1 基因 96121524 位的多态性与子痫前期易感性可能存在相关性。
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