Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL 60612-7344, USA.
Department of Microbiology and Immunology, University of Illinois College of Medicine, Chicago, IL 60612-7344, USA.
Trends Immunol. 2021 May;42(5):367-368. doi: 10.1016/j.it.2021.03.009. Epub 2021 Mar 30.
Animal studies and explant cultures of human lymphoid tissues do not reliably model human vaccine responses. A remarkable strategy for reassociation of human tonsillar cells in ex vivo culture leads to organoid formation and provides an exciting new tool to probe human humoral immune responses to infection.
动物研究和人淋巴组织的器官培养不能可靠地模拟人类疫苗反应。一种引人注目的策略，即重新组合人扁桃体细胞的体外培养，导致类器官的形成，并为探索人类对感染的体液免疫反应提供了令人兴奋的新工具。
