Department of Dermatology, Ajou University School of Medicine, Suwon, Korea.
Am J Dermatopathol. 2021 Aug 1;43(8):583-584. doi: 10.1097/DAD.0000000000001863.
Xanthomas present clinically as eruptive, tuberoeruptive, tuberous, tendinous, or planar forms. Among these, eruptive xanthoma (EX) is characterized by sudden development of multiple, red-to-yellow papules, each less than 5 mm in diameter, on the extensor surface of the extremities and the buttock area. EX is often associated with severe hypertriglyceridemia, underlying diabetes, obesity, or excessive alcohol intake. Histologically EX is characterized by foamy cells, which are lipid-laden macrophages surrounded by lymphoid cells, histiocytes, and neutrophils; however, mucin deposition is not a typical feature. Herein, we report a rare case of xanthoma with diffuse, abundant mucin deposition.
黄瘤病临床上表现为发疹性、结节状、结节状、腱状或扁平状。其中,发疹性黄瘤(EX)的特征是四肢伸面和臀部突然出现多个直径小于 5 毫米的红色至黄色丘疹。EX 常与严重的高三酰甘油血症、潜在的糖尿病、肥胖或过度饮酒有关。组织学上,EX 的特征是泡沫细胞,即被淋巴细胞、组织细胞和中性粒细胞包围的富含脂质的巨噬细胞;然而,粘蛋白沉积不是其典型特征。在此,我们报告一例罕见的弥漫性、大量粘蛋白沉积的黄瘤病。