意外真皮注射缓释丁丙诺啡后皮肤坏死

Skin Necrosis Following Inadvertent Dermal Injection of Extended-release Buprenorphine.

作者信息

Crouse Ericka, Haught Justin, Tobarran Natasha, Nichols Cameron, Cumpston Kirk L, Wills Brandon K

机构信息

Department of Pharmacotherapy & Outcomes Science, School of Pharmacy, Virginia Commonwealth University, Richmond, Virginia (EC), Department of Dermatology, Virginia Commonwealth University Health System, Richmond, Virginia (JH, CN), Virginia Poison Center, Division of Clinical Toxicology, Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond, Virginia (NT, KC, BW), Department of Emergency Medicine, Virginia Commonwealth University Health System, Richmond, Virginia (NT, KC, BW).

出版信息

J Addict Med. 2022;16(2):242-245. doi: 10.1097/ADM.0000000000000846.

DOI:10.1097/ADM.0000000000000846

PMID:33795578

Abstract

INTRODUCTION

Extended-release subcutaneous buprenorphine injection is a relatively new formulation and clinicians are still gaining experience with its use. There is sparse literature available on adverse events. We describe a case of skin necrosis associated with the injection site of extended-release buprenorphine.

CASE REPORT

A 35-year-old reported immediate swelling and eventual skin breakdown near his buprenorphine injection site. He was found to have ulceration down to the subcutis with no evidence of infection. The patient followed up with dermatology and underwent debridement of the site. The injection site healed with scar formation.

DISCUSSION

Although mild to moderate adverse events related to the injection site have been reported in Phase 3 studies of extended-release buprenorphine injection, this is a rare case of skin necrosis requiring surgical intervention and excision of the depot.

CONCLUSIONS

This case highlights the potential complication of skin necrosis after inadvertent dermal of extended-release buprenorphine and reviews proper administration techniques.

摘要