Deshpande Juilee S, Sundrani Deepali P, Sahay Akriti S, Gupte Sanjay A, Joshi Sadhana R
Mother and Child Health, Interactive Research School for Health Affairs (IRSHA), Bharati Vidyapeeth (Deemed to be) University, Pune, India.
Gupte Hospital and Research Centre, Pune, India.
Hypertens Res. 2021 Jul;44(7):756-769. doi: 10.1038/s41440-021-00647-9. Epub 2021 Apr 1.
Preeclampsia is a multisystem, multiorgan hypertensive disorder of pregnancy responsible for maternal and perinatal morbidity and mortality in low- and middle-income countries. The classic diagnostic features hold less specificity for preeclampsia and its associated adverse outcomes, suggesting a need for specific and reliable biomarkers for the early prediction of preeclampsia. The imbalance of pro- and antiangiogenic circulatory factors contributes to the pathophysiology of preeclampsia. Several studies have examined the profile of angiogenic factors in preeclampsia to search for a biomarker that will improve the diagnostic ability of preeclampsia and associated adverse outcomes. This may help in more efficient patient management and the reduction of associated health care costs. This article reviews the findings from previous studies published to date on angiogenic factors and suggests a need to apply a multivariable model from the beginning of pregnancy and continuing throughout gestation for the early and specific prediction of preeclampsia.
子痫前期是一种多系统、多器官的妊娠高血压疾病，在低收入和中等收入国家会导致孕产妇和围产儿发病及死亡。子痫前期的经典诊断特征对于子痫前期及其相关不良结局的特异性较低，这表明需要有特异性且可靠的生物标志物来早期预测子痫前期。促血管生成和抗血管生成循环因子的失衡促成了子痫前期的病理生理过程。多项研究已对子痫前期中血管生成因子的概况进行了研究，以寻找一种能提高子痫前期及其相关不良结局诊断能力的生物标志物。这可能有助于更有效地管理患者并降低相关医疗保健成本。本文回顾了迄今为止发表的关于血管生成因子的既往研究结果，并表明需要从妊娠开始直至整个孕期应用多变量模型来早期、特异性地预测子痫前期。
