Dawson K P, Richardson W W
Aust N Z J Med. 1977 Aug;7(4):373-9. doi: 10.1111/j.1445-5994.1977.tb04398.x.
The main clinical and laboratory findings in a group of 50 children with acute nephritis are described and discussed. All the group had evidence of a streptococcal aetiology. The wide spectrum of presenting complaints, the age distribution and the high incidence among Maori children are noted. The severity of the disease, as indicated by features such as hypertensive crisis, was greater than expected. Fifty per cent of our patients experienced one or more of our defined complications. Encephalopathy was seen in 12% of all patients and severe hypertension in 34%. The striking feature of the laboratory findings was the wide variation in complement changes. No constant patterns emerged which would have implicated either the "classical" or "alternate" pathway for the activation of complement in these patients. An unexpected finding was the relatively high incidence of a transient C3 nephritic factor in post-streptococcal cases. We found also that fibrin degradation products were present in high concentrations in the urine of patients with post-streptococcal nephritis, again an unexpected finding.
本文描述并讨论了一组50例急性肾炎患儿的主要临床和实验室检查结果。所有患儿均有链球菌感染病因的证据。文中指出了患儿出现的各种主诉、年龄分布以及毛利族儿童中的高发病率。由高血压危象等特征表明的疾病严重程度高于预期。我们的患者中有50%经历了一种或多种我们定义的并发症。12%的患者出现脑病，34%的患者出现严重高血压。实验室检查结果的显著特点是补体变化差异很大。在这些患者中，没有出现能表明补体激活涉及“经典”或“替代”途径的恒定模式。一个意外发现是，在链球菌感染后病例中，短暂性C3肾炎因子的发病率相对较高。我们还发现，链球菌感染后肾炎患者的尿液中纤维蛋白降解产物浓度很高，这同样是一个意外发现。
