Department of Dermatology and Venereology, Hasanuddin University, Dr. Wahidin Sudirohusodo Central Public Hospital, Makassar, Indonesia.
Pan Afr Med J. 2020 Dec 29;37:383. doi: 10.11604/pamj.2020.37.383.27380. eCollection 2020.
Cutaneous metastases due to internal malignancies are rare but, in some cases, may present as the first manifestation of an undiagnosed malignancy. A 62-year-old female presented with itchy reddish patch on the left neck which spread to the left shoulder, arm, breast, and back four weeks prior to admission. Ten days later, vesicles emerged, ruptured, and ulcerated. The patient denied any history of breast lump. Skin biopsy showed diffuse dermal nests of tumor cells infiltrating to the collagen bundles and fat tissue, which was consistent with cutaneous metastasis from the breast cancer. The patient refused further workup and treatment and eventually passed away. This case showed the importance of conducting a comprehensive evaluation in cutaneous lesions presenting with early or sudden onset, rapid evolution, tendency to bleed, that do not resolve with treatment.
皮肤转移性肿瘤源于内部恶性肿瘤,较为罕见,但在某些情况下,可能是无明确诊断的恶性肿瘤的首发表现。一名 62 岁女性,入院前四周出现左侧颈部红斑伴瘙痒,逐渐蔓延至左侧肩部、手臂、乳房和背部。十天后,红斑上出现水疱,破溃后形成溃疡。患者否认乳房有肿块。皮肤活检显示弥漫性真皮巢状肿瘤细胞浸润至胶原束和脂肪组织,符合乳腺癌皮肤转移。患者拒绝进一步检查和治疗,最终死亡。该病例表明,对于早期或突然发作、迅速进展、易出血、治疗后不缓解的皮肤病变,进行全面评估非常重要。