Klinkhoff A V, Bellamy N, Bombardier C, Carette S, Chalmers A, Esdaile J M, Goldsmith C, Tugwell P, Smythe H A, Buchanan W W
Division of Rheumatology, University of British Columbia, Vancouver, Canada.
J Rheumatol. 1988 Mar;15(3):492-4.
This experiment was designed to test the feasibility of reducing interobserver variability of the joint examination by agreement on a standard examination. Six rheumatologists independently examined 6 patients with rheumatoid arthritis (RA) in predetermined order, before and after a standardization of examination techniques. Results of an analysis of variance showed a reduction of the percent of variability due to observers from 13.8%, before standardization, to 3.2% after standardization, and an improvement in the percent variability related to patient differences from 70.7%, before standardization, to 86.3% after standardization. Such a reduction in observer variability has a potential for allowing a reduction in sample sizes required for RA clinical trials.
本实验旨在通过就标准检查达成一致来测试降低关节检查中观察者间变异性的可行性。六位风湿病学家按照预定顺序，在检查技术标准化前后，分别对6例类风湿关节炎（RA）患者进行独立检查。方差分析结果显示，观察者导致的变异性百分比从标准化前的13.8%降至标准化后的3.2%，与患者差异相关的变异性百分比从标准化前的70.7%提高到标准化后的86.3%。观察者变异性的这种降低有可能减少RA临床试验所需的样本量。
