• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

动脉内输注自体骨髓单个核细胞联合静脉注射脑蛋白水解物治疗大脑中动脉缺血性卒中:病例报告

Intra-arterial infusion of autologous bone marrow mononuclear cells combined with intravenous injection of cerebrolysin in the treatment of middle cerebral artery ischemic stroke: Case report.

作者信息

Le Vien C, Nguyen Ngoc H, Le Song H

机构信息

Stroke Center, 108 Military Central Hospital, Ha Noi, Vietnam.

108 Military Central Hospital, Ha Noi, Vietnam.

出版信息

SAGE Open Med Case Rep. 2021 Mar 17;9:2050313X211002313. doi: 10.1177/2050313X211002313. eCollection 2021.

DOI:10.1177/2050313X211002313
PMID:33796315
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7975445/
Abstract

We present a patient with severe middle cerebral artery occlusion who received an intra-arterial infusion of autologous bone marrow stem cells combined with Cerebrolysin IV. The patient was evaluated before and after treatment using the National Institutes of Health Stroke Scale, the Medical Research Council Muscle Scale, Modified Brunnstrom Classification, Barthel Index and modified Rankin Scale. After the therapy, the patient showed good outcome with functional as well as neurological improvements especially in terms of functional motor recovery without any side effects. Further controlled studies are needed to find possible side effects and establish net efficacy.

摘要

我们报告了一名患有严重大脑中动脉闭塞的患者,其接受了自体骨髓干细胞与脑蛋白水解物静脉输注相结合的动脉内输注治疗。使用美国国立卫生研究院卒中量表、医学研究理事会肌肉量表、改良Brunnstrom分级、Barthel指数和改良Rankin量表对该患者治疗前后进行了评估。治疗后,患者在功能和神经方面均有改善,尤其是在功能运动恢复方面取得了良好的效果,且无任何副作用。需要进一步的对照研究来发现可能的副作用并确定净疗效。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/087e/7975445/686af006a2c2/10.1177_2050313X211002313-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/087e/7975445/931413cbad35/10.1177_2050313X211002313-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/087e/7975445/686af006a2c2/10.1177_2050313X211002313-fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/087e/7975445/931413cbad35/10.1177_2050313X211002313-fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/087e/7975445/686af006a2c2/10.1177_2050313X211002313-fig2.jpg

相似文献

1
Intra-arterial infusion of autologous bone marrow mononuclear cells combined with intravenous injection of cerebrolysin in the treatment of middle cerebral artery ischemic stroke: Case report.动脉内输注自体骨髓单个核细胞联合静脉注射脑蛋白水解物治疗大脑中动脉缺血性卒中:病例报告
SAGE Open Med Case Rep. 2021 Mar 17;9:2050313X211002313. doi: 10.1177/2050313X211002313. eCollection 2021.
2
Intra-arterial bone marrow mononuclear cells (BM-MNCs) transplantation in acute ischemic stroke (IBIS trial): protocol of a phase II, randomized, dose-finding, controlled multicenter trial.急性缺血性卒中动脉内骨髓单个核细胞(BM-MNCs)移植(IBIS试验):一项II期、随机、剂量探索、对照多中心试验方案
Int J Stroke. 2015 Oct;10(7):1149-52. doi: 10.1111/ijs.12520. Epub 2015 Jun 4.
3
A Phase 2 Randomized, Sham-Controlled Trial of Internal Carotid Artery Infusion of Autologous Bone Marrow-Derived ALD-401 Cells in Patients With Recent Stable Ischemic Stroke (RECOVER-Stroke).一项自体骨髓源性 ALD-401 细胞经颈内动脉输注治疗近期稳定缺血性脑卒中患者的 2 期随机、假手术对照临床试验(RECOVER-Stroke)。
Circulation. 2019 Jan 8;139(2):192-205. doi: 10.1161/CIRCULATIONAHA.117.030659.
4
Intra-arterial infusion of autologous bone marrow mononuclear cells in patients with moderate to severe middle cerebral artery acute ischemic stroke.经动脉内输注自体骨髓单个核细胞治疗中度至重度大脑中动脉急性缺血性脑卒中。
Cell Transplant. 2012;21 Suppl 1:S13-21. doi: 10.3727/096368912x612512.
5
Intra-arterial Infusion of Autologous Bone Marrow Mononuclear Stem Cells in Subacute Ischemic Stroke Patients.亚急性缺血性中风患者自体骨髓单个核干细胞的动脉内输注
Front Neurol. 2016 Dec 16;7:228. doi: 10.3389/fneur.2016.00228. eCollection 2016.
6
Cerebrolysin in patients with acute ischemic stroke in Asia: results of a double-blind, placebo-controlled randomized trial.亚洲急性缺血性脑卒中患者的脑活素治疗:一项双盲、安慰剂对照的随机临床试验结果。
Stroke. 2012 Mar;43(3):630-6. doi: 10.1161/STROKEAHA.111.628537. Epub 2012 Jan 26.
7
Intravenous autologous bone marrow mononuclear stem cell therapy for ischemic stroke: a multicentric, randomized trial.静脉内自体骨髓单个核干细胞治疗缺血性脑卒中:一项多中心、随机试验。
Stroke. 2014 Dec;45(12):3618-24. doi: 10.1161/STROKEAHA.114.007028. Epub 2014 Nov 6.
8
Randomized Assessment of the Safety and Efficacy of Intra-Arterial Infusion of Autologous Stem Cells in Subacute Ischemic Stroke.随机评估自体干细胞动脉内输注治疗亚急性缺血性脑卒中的安全性和有效性。
AJNR Am J Neuroradiol. 2018 May;39(5):899-904. doi: 10.3174/ajnr.A5586. Epub 2018 Mar 15.
9
Response to intra-arterial and combined intravenous and intra-arterial thrombolytic therapy in patients with distal internal carotid artery occlusion.颈内动脉远端闭塞患者对动脉内及静脉联合动脉内溶栓治疗的反应
Stroke. 2002 Jul;33(7):1821-6. doi: 10.1161/01.str.0000020363.23725.67.
10
Intra-Arterial Injection of Autologous Bone Marrow-Derived Mononuclear Cells in Ischemic Stroke Patients.缺血性中风患者自体骨髓来源单个核细胞的动脉内注射
Exp Clin Transplant. 2019 Jan;17(Suppl 1):239-241. doi: 10.6002/ect.MESOT2018.P102.

引用本文的文献

1
Treatment of ischemic stroke with modified mesenchymal stem cells.用改良间充质干细胞治疗缺血性脑卒中。
Int J Med Sci. 2022 Jun 27;19(7):1155-1162. doi: 10.7150/ijms.74161. eCollection 2022.
2
Cell Therapy of Stroke: Do the Intra-Arterially Transplanted Mesenchymal Stem Cells Cross the Blood-Brain Barrier?脑卒中的细胞治疗:经动脉移植的间充质干细胞是否能穿越血脑屏障?
Cells. 2021 Nov 3;10(11):2997. doi: 10.3390/cells10112997.

本文引用的文献

1
Neurocognitive robot-assisted rehabilitation of hand function: a randomized control trial on motor recovery in subacute stroke.神经认知机器人辅助手部功能康复:亚急性期脑卒中运动功能恢复的随机对照试验。
J Neuroeng Rehabil. 2020 Aug 24;17(1):115. doi: 10.1186/s12984-020-00746-7.
2
Regenerative Rehabilitation for Stroke Recovery by Inducing Synergistic Effects of Cell Therapy and Neurorehabilitation on Motor Function: A Narrative Review of Pre-Clinical Studies.细胞治疗与神经康复协同作用促进脑卒中康复的再生康复治疗:临床前研究的叙事性综述。
Int J Mol Sci. 2020 Apr 29;21(9):3135. doi: 10.3390/ijms21093135.
3
Efficacy and safety of cerebrolysin in neurorecovery after moderate-severe traumatic brain injury: results from the CAPTAIN II trial.
脑活素治疗中重度颅脑损伤后神经功能恢复的疗效和安全性:CAPTAIN II 试验结果。
Neurol Sci. 2020 May;41(5):1171-1181. doi: 10.1007/s10072-019-04181-y. Epub 2020 Jan 2.
4
Effectiveness of interventions to improve hand motor function in individuals with moderate to severe stroke: a systematic review protocol.干预措施改善中重度脑卒中患者手部运动功能的效果:系统评价方案。
BMJ Open. 2019 Sep 27;9(9):e032413. doi: 10.1136/bmjopen-2019-032413.
5
Randomized controlled trial of Cerebrolysin's effects on long-term histological outcomes and functional recovery in rats with moderate closed head injury.脑蛋白水解物对中度闭合性颅脑损伤大鼠长期组织学结果及功能恢复影响的随机对照试验
J Neurosurg. 2019 Sep 6;133(4):1072-1082. doi: 10.3171/2019.6.JNS191027. Print 2020 Oct 1.
6
Stroke in the 21 Century: A Snapshot of the Burden, Epidemiology, and Quality of Life.21世纪的中风:负担、流行病学及生活质量概览
Stroke Res Treat. 2018 Nov 27;2018:3238165. doi: 10.1155/2018/3238165. eCollection 2018.
7
Evolution of the Modified Rankin Scale and Its Use in Future Stroke Trials.改良Rankin量表的演变及其在未来卒中试验中的应用。
Stroke. 2017 Jul;48(7):2007-2012. doi: 10.1161/STROKEAHA.117.017866. Epub 2017 Jun 16.
8
Using the National Institutes of Health Stroke Scale: A Cautionary Tale.使用美国国立卫生研究院卒中量表:一个警示故事。
Stroke. 2017 Feb;48(2):513-519. doi: 10.1161/STROKEAHA.116.015434. Epub 2017 Jan 11.
9
Intra-arterial Infusion of Autologous Bone Marrow Mononuclear Stem Cells in Subacute Ischemic Stroke Patients.亚急性缺血性中风患者自体骨髓单个核干细胞的动脉内输注
Front Neurol. 2016 Dec 16;7:228. doi: 10.3389/fneur.2016.00228. eCollection 2016.
10
Cerebrolysin combined with rehabilitation promotes motor recovery in patients with severe motor impairment after stroke.脑蛋白水解物联合康复治疗可促进脑卒中后严重运动功能障碍患者的运动功能恢复。
BMC Neurol. 2016 Mar 2;16:31. doi: 10.1186/s12883-016-0553-z.