• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

相似文献

1
Intratumoral Heterogeneity in Uveal Melanoma.葡萄膜黑色素瘤的肿瘤内异质性
Ocul Oncol Pathol. 2021 Mar;7(1):17-25. doi: 10.1159/000508517. Epub 2020 Aug 25.
2
Uveal Melanoma Biopsy: A Review.葡萄膜黑色素瘤活检：综述
Cancers (Basel). 2019 Jul 30;11(8):1075. doi: 10.3390/cancers11081075.
3
Uveal Melanoma with Histopathologic Intratumoral Heterogeneity Associated with Gene Expression Profile Discordance.伴有组织病理学肿瘤内异质性且与基因表达谱不一致相关的葡萄膜黑色素瘤
Ocul Oncol Pathol. 2017 Jul;3(2):156-160. doi: 10.1159/000453616. Epub 2016 Dec 29.
4
Molecular Insights and Emerging Strategies for Treatment of Metastatic Uveal Melanoma.转移性葡萄膜黑色素瘤治疗的分子见解与新兴策略
Cancers (Basel). 2020 Sep 25;12(10):2761. doi: 10.3390/cancers12102761.
5
Genetic prognostication in uveal melanoma.葡萄膜黑色素瘤的遗传预后。
Acta Ophthalmol. 2018 Jun;96(4):331-347. doi: 10.1111/aos.13580. Epub 2017 Nov 4.
6
Prognostication of uveal melanoma is simple and highly predictive using The Cancer Genome Atlas (TCGA) classification: A review.使用癌症基因组图谱（TCGA）分类法对葡萄膜黑色素瘤进行预后判断简单且具有高度预测性：综述。
Indian J Ophthalmol. 2019 Dec;67(12):1959-1963. doi: 10.4103/ijo.IJO_1589_19.
7
Is accurate routine cancer prognostication psychologically harmful? 5-year outcomes of life expectancy prognostication in uveal melanoma survivors.准确的常规癌症预后预测是否会在心理上造成伤害？葡萄膜黑色素瘤幸存者的预期寿命预后 5 年结果。
J Cancer Surviv. 2022 Apr;16(2):408-420. doi: 10.1007/s11764-021-01036-4. Epub 2021 Apr 19.
8
Improved Uveal Melanoma Copy Number Subtypes Including an Ultra-High-Risk Group.改良的葡萄膜黑色素瘤拷贝数亚型，包括一个超高风险组。
Ophthalmol Sci. 2022 Jan 30;2(2):100121. doi: 10.1016/j.xops.2022.100121. eCollection 2022 Jun.
9
Prognostic value of chromosomal imbalances, gene mutations, and BAP1 expression in uveal melanoma.葡萄膜黑色素瘤中染色体失衡、基因突变和 BAP1 表达的预后价值。
Genes Chromosomes Cancer. 2018 Aug;57(8):387-400. doi: 10.1002/gcc.22541.
10
Applying Single-Cell Technology in Uveal Melanomas: Current Trends and Perspectives for Improving Uveal Melanoma Metastasis Surveillance and Tumor Profiling.单细胞技术在葡萄膜黑色素瘤中的应用：改善葡萄膜黑色素瘤转移监测和肿瘤分析的当前趋势与展望
Front Mol Biosci. 2021 Jan 6;7:611584. doi: 10.3389/fmolb.2020.611584. eCollection 2020.

引用本文的文献

1
Heterogeneity and molecular landscape of melanoma: implications for targeted therapy.黑色素瘤的异质性和分子特征：对靶向治疗的影响。
Mol Biomed. 2024 May 10;5(1):17. doi: 10.1186/s43556-024-00182-2.

本文引用的文献

1
Uveal Melanoma Biopsy: A Review.葡萄膜黑色素瘤活检：综述
Cancers (Basel). 2019 Jul 30;11(8):1075. doi: 10.3390/cancers11081075.
2
Uveal melanoma: relatively rare but deadly cancer.葡萄膜黑色素瘤：相对罕见但致命的癌症。
Eye (Lond). 2017 Feb;31(2):241-257. doi: 10.1038/eye.2016.275. Epub 2016 Dec 2.
3
Transvitreal Retinochoroidal Biopsy Provides a Representative Sample From Choroidal Melanoma for Detection of Chromosome 3 Aberrations.经玻璃体视网膜脉络膜活检可为脉络膜黑色素瘤提供用于检测3号染色体畸变的代表性样本。
Invest Ophthalmol Vis Sci. 2015 Sep;56(10):5917-24. doi: 10.1167/iovs.15-17349.
4
Uveal melanoma: estimating prognosis.葡萄膜黑色素瘤：预后评估
Indian J Ophthalmol. 2015 Feb;63(2):93-102. doi: 10.4103/0301-4738.154367.
5
Case report: an atypical peripapillary uveal melanoma.病例报告：非典型性视盘周围脉络膜黑色素瘤。
BMC Ophthalmol. 2014 Feb 3;14:13. doi: 10.1186/1471-2415-14-13.
6
Collaborative Ocular Oncology Group report number 1: prospective validation of a multi-gene prognostic assay in uveal melanoma.协作性眼肿瘤学组报告第 1 号：在葡萄膜黑色素瘤中前瞻性验证多基因预后检测。
Ophthalmology. 2012 Aug;119(8):1596-603. doi: 10.1016/j.ophtha.2012.02.017. Epub 2012 Apr 21.
7
Genetics of uveal melanoma and cutaneous melanoma: two of a kind?葡萄膜黑色素瘤和皮肤黑色素瘤的遗传学：同类的两种疾病？
Dermatol Res Pract. 2010;2010:360136. doi: 10.1155/2010/360136. Epub 2010 Jun 6.
8
Genetic heterogeneity in uveal melanoma assessed by multiplex ligation-dependent probe amplification.通过多重连接依赖探针扩增评估葡萄膜黑色素瘤中的基因异质性。
Invest Ophthalmol Vis Sci. 2010 Oct;51(10):4898-905. doi: 10.1167/iovs.09-5004. Epub 2010 May 19.
9
Chromosome 3 intratumor heterogeneity in uveal melanoma.葡萄膜黑色素瘤中3号染色体的肿瘤内异质性
Invest Ophthalmol Vis Sci. 2009 Feb;50(2):500-4. doi: 10.1167/iovs.08-2279. Epub 2008 Sep 29.
10
The COMS randomized trial of iodine 125 brachytherapy for choroidal melanoma: V. Twelve-year mortality rates and prognostic factors: COMS report No. 28.125碘近距离放射治疗脉络膜黑色素瘤的COMS随机试验：V. 12年死亡率及预后因素：COMS报告第28号
Arch Ophthalmol. 2006 Dec;124(12):1684-93. doi: 10.1001/archopht.124.12.1684.

葡萄膜黑色素瘤的肿瘤内异质性

Intratumoral Heterogeneity in Uveal Melanoma.

作者信息

Fonseca Cristina, Pinto-Proença Rita, Bergeron Sabrina, Pires Luís Miguel, Fernandes Júlia, Carreira Isabel Marques, Burnier Miguel N, Proença Rui

机构信息

Ocular Oncology Reference Center, Centro Hospitalar Universitário de Coimbra, Coimbra, Portugal.

MUHC - McGill University Ocular Pathology and Translational Research Laboratory, Montreal, Québec, Canada.

出版信息

Ocul Oncol Pathol. 2021 Mar;7(1):17-25. doi: 10.1159/000508517. Epub 2020 Aug 25.

DOI:10.1159/000508517
PMID:33796512
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7989676/
Abstract

Tumor biopsies in uveal melanoma (UM) serve mainly the purpose of prognostication and assessment of individual metastatic risk, but can be used for diagnosis in selected cases. The importance of precise information is paramount for selecting adequate surveillance protocols, patient counseling, and optimization of treatment strategies. However, intratumoral heterogeneity and sample representativity are major concerns and can interfere with the correct prediction of the patient's prognosis. We report a series of cases of UM with distinct morphologically identifiable areas, highlighting the differences in clinical behavior, as well as histopathological and genetic features.

摘要

葡萄膜黑色素瘤（UM）的肿瘤活检主要用于预后评估和个体转移风险评估，但在某些特定病例中也可用于诊断。准确信息对于选择合适的监测方案、患者咨询以及优化治疗策略至关重要。然而，肿瘤内异质性和样本代表性是主要问题，可能会干扰对患者预后的正确预测。我们报告了一系列具有形态学可识别不同区域的UM病例，突出了临床行为、组织病理学和基因特征的差异。