Sweeney R W, Beech J, Simmons R D, Soma L R
Department of Clinical Studies, New Bolton Center, University of Pennsylvania School of Veterinary Medicine, Kennett Square.
J Vet Pharmacol Ther. 1988 Mar;11(1):103-8. doi: 10.1111/j.1365-2885.1988.tb00102.x.
The pharmacokinetics of ticarcillin and clavulanic acid following administration by the intravenous (i.v.) and intramuscular (i.m.) routes were investigated in six normal adult horses. Following i.v. administration, the ticarcillin disposition data conformed to a two-compartment model with an elimination half-life of 1.0 h. The disposition of clavulanic acid was described by a one-compartment model with an elimination half-life of 0.40 h. Following i.m. administration, the half-lives of both drugs were prolonged (ticarcillin 1.8 h, clavulanic acid 1.2 h). The bioavailability of ticarcillin was 84.4% and clavulanic acid 94.3%.
在六匹正常成年马中研究了替卡西林和克拉维酸经静脉注射（i.v.）和肌肉注射（i.m.）给药后的药代动力学。静脉注射给药后，替卡西林的处置数据符合二室模型，消除半衰期为1.0小时。克拉维酸的处置情况由一室模型描述，消除半衰期为0.40小时。肌肉注射给药后，两种药物的半衰期均延长（替卡西林为1.8小时，克拉维酸为1.2小时）。替卡西林的生物利用度为84.4%，克拉维酸为94.3%。
