在资源匮乏地区使用念珠菌评分预测儿科重症监护病房中的念珠菌感染
Predicting Candida Infection in Pediatric Intensive Care Unit using Candida Score in a Low-Resource Setting.
作者信息
Risandy Dicky Ari, Rusmawatiningtyas Desy, Makrufardi Firdian, Herini Elisabeth Siti
机构信息
Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia.
出版信息
Glob Pediatr Health. 2021 Mar 19;8:2333794X21999152. doi: 10.1177/2333794X21999152. eCollection 2021.
Candida infection was previously thought to be rare in intensive care. With the increased use of broad-spectrum antibiotics, the incidence of candida infection increased significantly. Case-control study was done in patients ≤18 years of age treated for 3 days or more in Pediatric Intensive Care Unit (PICU) Dr. Sardjito General Hospital, Yogyakarta from January 2014 to December 2016. Overall, 43 children were included in this study as a case group with positive candida culture and 43 children as a control group with no candida culture. Cut off point of candida score is ≥3 from our subjects. The area under curve (AUC) value for cut off ≥3 was moderate (0,72). Candida score ≥3 has an odd ratio (OR) 6.8 (95% CI 2.4-18.6) with < .05. All of confounding factors in candida infection have no association with > .05. Candida score can be used as predictor of candida infection in PICU.
念珠菌感染以前被认为在重症监护中很少见。随着广谱抗生素使用的增加，念珠菌感染的发生率显著上升。2014年1月至2016年12月，在日惹市萨迪托综合医院儿科重症监护病房（PICU）对年龄≤18岁且接受治疗3天或更长时间的患者进行了病例对照研究。总体而言，本研究纳入了43名念珠菌培养阳性的儿童作为病例组，43名无念珠菌培养的儿童作为对照组。我们研究对象的念珠菌评分截断点为≥3。截断值≥3时的曲线下面积（AUC）值为中等（0.72）。念珠菌评分≥3的比值比（OR）为6.8（95%置信区间2.4 - 18.6），P < 0.05。念珠菌感染的所有混杂因素与P > 0.05均无关联。念珠菌评分可作为PICU念珠菌感染的预测指标。
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