Risandy Dicky Ari, Rusmawatiningtyas Desy, Makrufardi Firdian, Herini Elisabeth Siti
Department of Child Health, Faculty of Medicine, Public Health and Nursing, Universitas Gadjah Mada/Dr. Sardjito General Hospital, Yogyakarta, Indonesia.
Glob Pediatr Health. 2021 Mar 19;8:2333794X21999152. doi: 10.1177/2333794X21999152. eCollection 2021.
Candida infection was previously thought to be rare in intensive care. With the increased use of broad-spectrum antibiotics, the incidence of candida infection increased significantly. Case-control study was done in patients ≤18 years of age treated for 3 days or more in Pediatric Intensive Care Unit (PICU) Dr. Sardjito General Hospital, Yogyakarta from January 2014 to December 2016. Overall, 43 children were included in this study as a case group with positive candida culture and 43 children as a control group with no candida culture. Cut off point of candida score is ≥3 from our subjects. The area under curve (AUC) value for cut off ≥3 was moderate (0,72). Candida score ≥3 has an odd ratio (OR) 6.8 (95% CI 2.4-18.6) with < .05. All of confounding factors in candida infection have no association with > .05. Candida score can be used as predictor of candida infection in PICU.
念珠菌感染以前被认为在重症监护中很少见。随着广谱抗生素使用的增加，念珠菌感染的发生率显著上升。2014年1月至2016年12月，在日惹市萨迪托综合医院儿科重症监护病房（PICU）对年龄≤18岁且接受治疗3天或更长时间的患者进行了病例对照研究。总体而言，本研究纳入了43名念珠菌培养阳性的儿童作为病例组，43名无念珠菌培养的儿童作为对照组。我们研究对象的念珠菌评分截断点为≥3。截断值≥3时的曲线下面积（AUC）值为中等（0.72）。念珠菌评分≥3的比值比（OR）为6.8（95%置信区间2.4 - 18.6），P < 0.05。念珠菌感染的所有混杂因素与P > 0.05均无关联。念珠菌评分可作为PICU念珠菌感染的预测指标。
