[甲氨蝶呤相关淋巴增殖性疾病早期发病酷似霍奇金淋巴瘤]
[Early onset of methotrexate-associated lymphoproliferative disorder mimicking Hodgkin's lymphoma].
作者信息
Burg Maria Rosa, Schneider Stefan W
机构信息
Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.
出版信息
Hautarzt. 2022 Jan;73(1):71-74. doi: 10.1007/s00105-021-04804-6. Epub 2021 Apr 1.
Long-term methotrexate (MTX) treatment is known to cause MTX-associated lymphoproliferative disorder (MTX-LPD). A 58-year-old woman with psoriasis vulgaris and pityriasis rubra pilaris was treated with a combination of MTX and ustekinumab for 4 months when she developed generalized lymphadenopathy. The initial histopathological analysis indicated Hodgkin's lymphoma; however, assessing the patient's clinical history revealed the diagnosis of MTX-LPD. To our knowledge, this is the first case of a MTX-LPD after only 4 months of treatment.
长期使用甲氨蝶呤（MTX）治疗已知会导致与MTX相关的淋巴增殖性疾病（MTX-LPD）。一名58岁患有寻常型银屑病和毛发红糠疹的女性，在接受MTX和乌司奴单抗联合治疗4个月后出现全身淋巴结肿大。最初的组织病理学分析表明为霍奇金淋巴瘤；然而，评估患者的临床病史后确诊为MTX-LPD。据我们所知，这是仅治疗4个月后发生MTX-LPD的首例病例。
Zotero 插件