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[甲氨蝶呤相关淋巴增殖性疾病早期发病酷似霍奇金淋巴瘤]

[Early onset of methotrexate-associated lymphoproliferative disorder mimicking Hodgkin's lymphoma].

作者信息

Burg Maria Rosa, Schneider Stefan W

机构信息

Klinik und Poliklinik für Dermatologie und Venerologie, Universitätsklinikum Hamburg-Eppendorf, Martinistr. 52, 20246, Hamburg, Deutschland.

出版信息

Hautarzt. 2022 Jan;73(1):71-74. doi: 10.1007/s00105-021-04804-6. Epub 2021 Apr 1.

DOI:10.1007/s00105-021-04804-6
PMID:33796880
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8755694/
Abstract

Long-term methotrexate (MTX) treatment is known to cause MTX-associated lymphoproliferative disorder (MTX-LPD). A 58-year-old woman with psoriasis vulgaris and pityriasis rubra pilaris was treated with a combination of MTX and ustekinumab for 4 months when she developed generalized lymphadenopathy. The initial histopathological analysis indicated Hodgkin's lymphoma; however, assessing the patient's clinical history revealed the diagnosis of MTX-LPD. To our knowledge, this is the first case of a MTX-LPD after only 4 months of treatment.

摘要

长期使用甲氨蝶呤（MTX）治疗已知会导致与MTX相关的淋巴增殖性疾病（MTX-LPD）。一名58岁患有寻常型银屑病和毛发红糠疹的女性，在接受MTX和乌司奴单抗联合治疗4个月后出现全身淋巴结肿大。最初的组织病理学分析表明为霍奇金淋巴瘤；然而，评估患者的临床病史后确诊为MTX-LPD。据我们所知，这是仅治疗4个月后发生MTX-LPD的首例病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f8/8755694/a47efb05a89b/105_2021_4804_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f8/8755694/a47efb05a89b/105_2021_4804_Fig1_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/12f8/8755694/a47efb05a89b/105_2021_4804_Fig1_HTML.jpg

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本文引用的文献

1
Lymphoproliferative disorders in rheumatoid arthritis: clinicopathological analysis of 76 cases in relation to methotrexate medication.类风湿关节炎中的淋巴增殖性疾病：76例与甲氨蝶呤用药相关的临床病理分析
J Rheumatol. 2007 Feb;34(2):322-31. Epub 2006 Nov 15.