Institute of Functional Genomics, University of Montpellier, CNRS, INSERM, 371 Av. du Doyen Gaston Giraud, 34090, Montpellier, France.
Department of Urgent and Post Urgent Psychiatry, CHU Montpellier, 371 Av. du Doyen Gaston Giraud, 34090, Montpellier, France.
Eat Weight Disord. 2022 Feb;27(1):307-315. doi: 10.1007/s40519-021-01180-x. Epub 2021 Apr 1.
Eating disorders (ED) are associated with an in increased risk of suicidal behaviours. Laxative abuse might alter the gut-brain axis signaling, that might be implicated in the pathophysiology of suicide. This study aims to determine the association between laxative misuse and suicide attempt (SA) and suicidal ideation (SI) in patients with ED.
277 patients with ED were recruited from an Eating Disorder Unit of Lapeyronie Academic Hospital, Montpellier, France. Sociodemographic and clinical data were collected. Chi-square and t test were used, with Bonferroni corrections where required. Multiple regression models assessed the relationships between laxative misuse, SA, and SI.
62 (22.4%) patients reported lifetime laxative misuse. They were more likely to have a history of SA than non-misusers [43.83 vs 19.9%, p < 0.001, odds ratio (OR) 3.68]. In the multivariate model, adjusted for other confounders, lifetime laxative misuse remained associated with SA (adjusted OR 3.79, p = 0.041). In past 28 days, patients with SA history reported misusing laxatives for more days than patients without SA history (6 vs 1.5 days, p = 0.01, adjusted for vomiting and ED severity). Laxative use days during past 28 days was associated with current SI, adjusted for vomiting in the same period (p = 0.017).
Current and lifetime laxative misuse were associated with SA history and current SI in patients with ED, at least in part independently of other suicide-related factors.
Level III cohort, cross-sectional study.
饮食失调（ED）与自杀行为的风险增加有关。滥用泻药可能会改变肠道-大脑轴的信号传递，这可能与自杀的病理生理学有关。本研究旨在确定 ED 患者中滥用泻药与自杀企图（SA）和自杀意念（SI）之间的关联。
从法国蒙彼利埃拉佩罗恩尼医院的饮食失调科招募了 277 名 ED 患者。收集了社会人口统计学和临床数据。使用卡方检验和 t 检验，并在需要时进行了 Bonferroni 校正。多回归模型评估了滥用泻药、SA 和 SI 之间的关系。
62 名（22.4%）患者报告有过滥用泻药的病史。他们有自杀史的可能性比非滥用者高[43.83%比 19.9%，p<0.001，优势比（OR）3.68]。在多变量模型中，调整了其他混杂因素后，滥用泻药与 SA 仍相关（调整后的 OR 3.79，p=0.041）。在过去 28 天内，有自杀史的患者报告滥用泻药的天数多于没有自杀史的患者[6 天比 1.5 天，p=0.01，调整了同期的呕吐和 ED 严重程度]。过去 28 天内使用泻药的天数与当前的 SI 相关，调整了同期的呕吐（p=0.017）。
ED 患者目前和过去滥用泻药与 SA 史和当前 SI 相关，至少部分独立于其他与自杀相关的因素。
三级队列，横断面研究。
