Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
Infect Disord Drug Targets. 2022;22(2):e310321192584. doi: 10.2174/1871526521666210331164552.
This paper aims to review clinical and preclinical evidence regarding new strategies for the prevention of vancomycin-induced nephrotoxicity.
Evidence from 2014 to the end of 2019 was included. Twelve animal studies and one clinical trial were evaluated.
Although the incidence of vancomycin-induced nephrotoxicity was not reduced significantly in the clinical trial, antioxidants reduced the incidence of vancomycin-induced nephrotoxicity in preclinical studies.
Antioxidants including vitamin C, vitamin E, cilastatin, melatonin, zingerone, rutin, naringenin, saffron, silymarin, and dexmedetomidine were nephroprotective against vancomycininduced nephrotoxicity in preclinical studies. The nephroprotective effects of these antioxidants must be confirmed before routine use in clinical practice.
本文旨在回顾有关预防万古霉素诱导性肾毒性的新策略的临床前和临床证据。
纳入了 2014 年底至 2019 年的证据。评估了 12 项动物研究和 1 项临床试验。
尽管临床试验中万古霉素诱导性肾毒性的发生率没有显著降低，但抗氧化剂可降低临床前研究中万古霉素诱导性肾毒性的发生率。
在临床前研究中，抗氧化剂包括维生素 C、维生素 E、西司他汀、褪黑素、姜酮、芦丁、柚皮苷、藏红花、水飞蓟素和右美托咪定对万古霉素诱导性肾毒性具有肾保护作用。在常规临床实践中使用这些抗氧化剂之前，必须确认其肾保护作用。
