Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences, P.O.Box: 14155/6451, 1417614411 Tehran, Iran.
Eur J Clin Pharmacol. 2013 Apr;69(4):747-54. doi: 10.1007/s00228-012-1406-3. Epub 2012 Sep 21.
Several strategies have been proposed for the prevention of vancomycin-induced nephrotoxicity. Here, we review available evidence supporting the respective strategies.
Data were collected by searching the Scopus, PubMed, and Medline databases and the Cochrane database of systematic reviews. The key words used as search terms were "vancomycin," "nephrotoxicity", "renal failure," "renal damage," "nephroprotective," "renoprotective", and "prevention." Prospective or retrospective observational animal studies that evaluated the effects of a modality for the prevention of vancomycin-induced nephrotoxicity was included.
Animal studies show beneficial effects of various antioxidants, such as erdosteine, vitamin E, vitamin C, N-acetylcysteine, caffeic acid phenethyl ester, and erythropoietin, in the prevention of vancomycin-induced nephrotoxicity. However, before these agents can be used in clinical practice, their potential benefits must be confirmed in future randomized controlled human studies.
已经提出了几种预防万古霉素相关性肾毒性的策略。在此，我们对支持这些策略的相关证据进行综述。
通过检索 Scopus、PubMed 和 Medline 数据库以及 Cochrane 系统评价数据库收集数据。检索的关键词为“万古霉素”、“肾毒性”、“肾衰竭”、“肾损伤”、“肾保护”、“肾保护”和“预防”。纳入了评价某种预防万古霉素相关性肾毒性的方法的影响的前瞻性或回顾性观察性动物研究。
动物研究显示，各种抗氧化剂如厄多司坦、维生素 E、维生素 C、N-乙酰半胱氨酸、咖啡酸苯乙酯和促红细胞生成素在预防万古霉素相关性肾毒性方面具有有益作用。然而，在这些药物可用于临床实践之前，必须在未来的随机对照人体研究中证实其潜在益处。
