Department of Rehabilitation Services.
Transplant and Regenerative Medicine Centre.
J Pediatr Gastroenterol Nutr. 2021 Jul 1;73(1):110-114. doi: 10.1097/MPG.0000000000003138.
With improved survival of children with intestinal failure (IF), it is important to examine the impact on long-term physical function, physical activity (PA), and fatigue and identify clinical factors that may be predictive of impairment.
Cross-sectional study in children with IF on parenteral nutrition (PN) compared with healthy age- and sex-matched controls (HCs). Assessments included: Paediatric Quality of Life (PedsQL) Physical Function subscale, PedsQL Multi-Dimensional Fatigue Scale, and PA Perceived Benefits and Barriers scale. PA was measured using an accelerometer. Medical data was collected by chart abstraction.
Participants included 21 children with IF (14 girls), median age 8.33 (interquartile range [IQR] 6.96-11.04) years and 33 HCs (20 boys), 8.25 (6.67-10.79) years. In those with IF, 13 (62%) were born prematurely with a median of 15 (7.5-24.5) in-patient hospitalizations. There was a significant difference (P = 0.033) in mean steps/day in children with IF (9709 +/- 3975) compared with HCs (13104 +/- 5416), and a correlation between moderate-to-vigorous PA and gestational age (r = 0.642, P = 0.010). Child and parent proxy scores indicate poorer physical function and greater fatigue in the IF group, along with a correlation between greater fatigue (r = -0.538, P = 0.012), poorer physical function (r = -0.0650, P = 0.0001) in children with more hospitalizations. Barriers to PA include "I am tired" and "I am worried about my line."
Children with IF present with lower levels of PA and physical function and greater fatigue compared with their peers. Ongoing development of medical and rehabilitation intervention strategies is vital to optimize outcomes.
随着肠衰竭（IF）患儿生存率的提高，检查其对长期身体功能、身体活动（PA）和疲劳的影响，并确定可能导致功能障碍的临床因素变得尤为重要。
对接受肠外营养（PN）的 IF 患儿与年龄和性别匹配的健康对照（HC）进行横断面研究。评估包括：儿科生活质量（PedsQL）身体功能子量表、PedsQL 多维疲劳量表和 PA 感知益处和障碍量表。使用加速度计测量 PA。通过图表摘录收集医疗数据。
参与者包括 21 名 IF 患儿（14 名女孩），中位年龄 8.33（四分位距 [IQR] 6.96-11.04）岁，33 名 HCs（20 名男孩），8.25（6.67-10.79）岁。IF 患儿中，13 名（62%）为早产儿，中位数住院 15 次（7.5-24.5）。IF 患儿平均每天的步数（9709 ± 3975）与 HCs（13104 ± 5416）相比有显著差异（P = 0.033），并且中高强度 PA 与胎龄呈正相关（r = 0.642，P = 0.010）。儿童和家长代理评分表明 IF 组的身体功能和疲劳感更差，且住院次数越多，疲劳感越强（r = -0.538，P = 0.012），身体功能越差（r = -0.0650，P = 0.0001）。PA 的障碍包括“我累了”和“我担心我的管路”。
与同龄人相比，IF 患儿的 PA 和身体功能水平较低，疲劳感更强。不断开发医疗和康复干预策略对于优化结果至关重要。
