接受原发性放化疗的复发性喉癌和下咽癌的预后影像变量：一项系统评价和荟萃分析。
Prognostic imaging variables for recurrent laryngeal and hypopharyngeal carcinoma treated with primary chemoradiotherapy: A systematic review and meta-analysis.
作者信息
Smits Hilde J G, Assili Sanam, Kauw Frans, Philippens Marielle E P, de Bree Remco, Dankbaar Jan W
机构信息
Department of Radiology, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands.
Department of Head and Neck Surgical Oncology, University Medical Center Utrecht, University of Utrecht, Utrecht, the Netherlands.
出版信息
Head Neck. 2021 Jul;43(7):2202-2215. doi: 10.1002/hed.26698. Epub 2021 Apr 2.
BACKGROUND
In this systematic review, we aim to identify prognostic imaging variables of recurrent laryngeal or hypopharyngeal carcinoma after chemoradiotherapy.
METHODS
A systematic search was performed in PubMed and EMBASE (1990-2020). The crude data and effect estimates were extracted for each imaging variable. The level of evidence of each variable was assessed and pooled risk ratios (RRs) were calculated.
RESULTS
Twenty-two articles were included in this review, 17 on computed tomography (CT) and 5 on magnetic resonance imaging (MRI) variables. We found strong evidence for the prognostic value of tumor volume at various cut-off points (pooled RRs ranging from 2.09 to 3.03). Anterior commissure involvement (pooled RR 2.19), posterior commissure involvement (pooled RR 2.44), subglottic extension (pooled RR 2.25), and arytenoid cartilage extension (pooled RR 2.10) were also strong prognostic factors.
CONCLUSION
Pretreatment tumor volume and involvement of several subsites are prognostic factors for recurrent laryngeal or hypopharyngeal carcinoma after chemoradiotherapy.
背景
在本系统评价中，我们旨在确定喉癌或下咽癌放化疗后复发的预后影像变量。
方法
在PubMed和EMBASE（1990 - 2020年）中进行了系统检索。提取每个影像变量的原始数据和效应估计值。评估每个变量的证据水平并计算合并风险比（RRs）。
结果
本评价纳入了22篇文章，其中17篇关于计算机断层扫描（CT）变量，5篇关于磁共振成像（MRI）变量。我们发现肿瘤体积在不同切点处的预后价值有强有力的证据（合并RRs范围为2.09至3.03）。前联合受累（合并RR 2.19）、后联合受累（合并RR 2.44）、声门下扩展（合并RR 2.25）和杓状软骨扩展（合并RR 2.10）也是强有力的预后因素。
结论
治疗前肿瘤体积和几个亚部位的受累情况是喉癌或下咽癌放化疗后复发的预后因素。
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