大鼠肾小球系膜细胞的糖脂：针对这些细胞的抗体与异球四糖神经酰胺发生特异性反应。
Glycolipids of rat glomerular mesangial cells: antibody against the cells reacts specifically to isoglobotetraosylceramide.
作者信息
Ohyama K, Hirabayashi Y, Mizoguchi K, Nagase M, Honda N, Nishimura K
机构信息
First Department of Medicine, Hamamatsu University School of Medicine, Japan.
出版信息
Jpn J Exp Med. 1988 Feb;58(1):15-9.
Cultured rat glomerular mesangial cells had relatively simple glycolipid composition which comprised mainly monoglycosylceramide, diglycosylceramide, isoglobotetraosylceramide and GM3. Beside these glycolipids, sulfatide, polar gangliosides and an unknown neutral glycolipid were detected in whole kidney and tubules. Polyclonal antibody against the cultured rat mesangial cells, which induced glomerular injury in vivo, bound specifically with isoglobotetraosylceramide.
培养的大鼠肾小球系膜细胞具有相对简单的糖脂组成，主要包括单糖基神经酰胺、二糖基神经酰胺、异球四糖基神经酰胺和GM3。除了这些糖脂外，在整个肾脏和肾小管中还检测到了硫脂、极性神经节苷脂和一种未知的中性糖脂。针对培养的大鼠系膜细胞的多克隆抗体在体内可诱导肾小球损伤，它能与异球四糖基神经酰胺特异性结合。
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