半乳糖凝集素-3 预测心力衰竭患者死亡率的系统评价和荟萃分析。
Galectin-3 in Predicting Mortality of Heart Failure: A Systematic Review and Meta-Analysis.
机构信息
Department of Cardiology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, China.
Key Laboratory of Integrative Chinese and Western Medicine for the Diagnosis and Treatment of Circulatory Diseases of Zhejiang Province, Hanzhou, China.
出版信息
Heart Surg Forum. 2021 Mar 30;24(2):E327-E332. doi: 10.1532/hsf.3547.
BACKGROUND
In recent years, galectin-3, an inflammatory marker, has been demonstrated to be closely related to cardiac fibrosis and heart failure. The purpose of this systematic review and meta-analysis is to define galectin-3 in predicting mortality of heart failure.
METHODS
PubMed, Embase, and the Cochrane Library were searched. A total of 1540 studies were identified, and of these studies, 19 involving 9217 patients were included in our meta-analysis.
RESULTS
The diagnostic hazard ratios of galectin-3 in predicting mortality in chronic heart failure patients was 1.13 (95% CI,:1.07-1.21 ) and 2.17 (95% CI:1.27-3.08) in acute heart failure (HF) patients.
CONCLUSIONS
Our meta-analysis shows that elevated levels of galectin-3 are associated with higher mortality in both acute and chronic heart failure patients.
背景
近年来，炎症标志物半乳糖凝集素-3 被证实与心肌纤维化和心力衰竭密切相关。本系统评价和荟萃分析的目的是确定半乳糖凝集素-3 在预测心力衰竭患者死亡率中的作用。
方法
检索了 PubMed、Embase 和 Cochrane 图书馆。共确定了 1540 项研究，其中 19 项研究（涉及 9217 名患者）纳入了我们的荟萃分析。
结果
半乳糖凝集素-3 预测慢性心力衰竭患者死亡率的诊断风险比为 1.13（95%CI：1.07-1.21），预测急性心力衰竭（HF）患者死亡率的风险比为 2.17（95%CI：1.27-3.08）。
结论
我们的荟萃分析表明，半乳糖凝集素-3 水平升高与急性和慢性心力衰竭患者的死亡率升高相关。
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