Appl Opt. 2021 Apr 1;60(10):2907-2911. doi: 10.1364/AO.418291.
There is a great need for cost-efficient non-invasive medical diagnostic tools for analyzing humanly exhaled air. Compared to present day methods, photoacoustic spectroscopy (PAS) can provide a compact and portable (bedside), sensitive and inexpensive solution. We demonstrate a novel portable photoacoustic spectroscopic platform for isotopic measurements of methane (). We identify and discriminate the - and isotopologues and determine their mixing ratio. An Allan deviation analysis shows that the noise equivalent concentration for is 200 ppt (pmol/mol) at 100 s of integration time, corresponding to a normalized noise equivalent absorption coefficient of 5.1×10, potentially making the PAS sensor a truly disruptive instrument for bedside monitoring using isotope tracers by providing real-time metabolism data to clinical personnel.
对于分析人体呼出的空气，人们非常需要经济高效的非侵入式医学诊断工具。与当今的方法相比，光声光谱（PAS）可以提供一种紧凑、便携（床边）、灵敏且廉价的解决方案。我们展示了一种用于测量甲烷（）同位素的新型便携式光声光谱平台。我们能够识别和区分-和-同位素，并确定它们的混合比。艾伦偏差分析表明，在 100 秒的积分时间内，对于的噪声等效浓度为 200 ppt（pmol/mol），对应的归一化噪声等效吸收系数为 5.1×10-7，这使得 PAS 传感器有可能成为一种真正具有颠覆性的仪器，通过为临床人员提供实时代谢数据，利用同位素示踪剂进行床边监测。
