Appl Opt. 2021 Apr 1;60(10):2912-2918. doi: 10.1364/AO.418517.
Muscle ischemia injury is the essence of compartment syndrome (CS). Photoacoustic (PA) imaging can monitor hemoglobin concentration changes in ischemic tissue by determining the state of light-absorbing molecules. This study investigated whether PA imaging can provide accurate CS monitoring. Rats received compression on the lower hind limb for 3 h to induce ischemia injury, followed by PA imaging of desired muscles for 24 h. PA intensities of the injured group were significantly lower than that in the control group. Histology findings correlated well with the PA findings. The results demonstrated that PA imaging could be a noninvasive and timely tool for clinically monitoring CS.
肌肉缺血性损伤是筋膜间室综合征（CS）的本质。光声（PA）成像是通过确定光吸收分子的状态来监测缺血组织中血红蛋白浓度的变化。本研究探讨了 PA 成像是否可以提供准确的 CS 监测。大鼠下肢接受 3 小时的压迫以诱导缺血性损伤，然后对所需肌肉进行 24 小时的 PA 成像。损伤组的 PA 强度明显低于对照组。组织学发现与 PA 发现密切相关。结果表明，PA 成像可以成为一种非侵入性的、及时的临床监测 CS 的工具。
