Wang Yupeng, Shao Feng
National Institute of Biological Sciences, Beijing, P.R. China.
National Institute of Biological Sciences, Beijing, P.R. China.
Mol Cell. 2021 Apr 1;81(7):1370-1371. doi: 10.1016/j.molcel.2021.03.005.
Using a forward-genetic screening of macrophages from randomly mutagenized mice, Kayagaki et al. (2021) identify NINJ1 that mediates plasma membrane rupture following various types of programmed cell death, an event previously thought to be passive.
通过对随机诱变小鼠的巨噬细胞进行正向遗传学筛选，Kayagaki等人（2021年）鉴定出了NINJ1，它介导了各种类型程序性细胞死亡后的质膜破裂，这一事件以前被认为是被动发生的。
