利用发育可塑性来塑造肾脏类器官。
Harnessing developmental plasticity to pattern kidney organoids.
机构信息
Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC, USA; Center for Biomolecular and Tissue Engineering, Duke University, Durham, NC, USA.
Developmental and Stem Cell Biology Program, Duke University School of Medicine, Durham, NC, USA.
出版信息
Cell Stem Cell. 2021 Apr 1;28(4):587-589. doi: 10.1016/j.stem.2021.03.009.
Methods for deriving the ureteric epithelium (UE) in vitro could improve understanding of kidney development and patterning. In this issue of Cell Stem Cell, Howden et al. (2021) identified transcriptionally distinct cell populations in human induced pluripotent stem cell (iPSC)-derived distal nephron (DN) epithelia that were inducible to UE phenotype within kidney organoids.
在体外获得输尿管上皮（UE）的方法可以提高对肾脏发育和模式形成的理解。在本期《Cell Stem Cell》杂志上，Howden 等人（2021）鉴定了人诱导多能干细胞（iPSC）衍生的远端肾单位（DN）上皮中具有不同转录特征的细胞群体，这些细胞在肾类器官中可诱导为 UE 表型。
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