Department of Medicine Huddinge, Karolinska Institutet, Huddinge, Sweden.
Department of Immunology, Genetics and Pathology, Rudbeck Laboratory, Uppsala University, Uppsala, Sweden; Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin Neurological Institute, Key Laboratory of Post-Neuroinjury Neuro-Repair and Regeneration in Central Nervous System, Ministry of Education and Tianjin City, Tianjin, 300052, China.
Exp Cell Res. 2021 May 15;402(2):112576. doi: 10.1016/j.yexcr.2021.112576. Epub 2021 Mar 31.
The brain vasculature has several specific features, one of them being the blood-brain barrier (BBB), which supports and protects the brain by allowing for the passage of oxygen and nutrients, while at the same time preventing passage of pathogens and toxins. The BBB also prevents efficient delivery of drugs to the brain, e.g. for treatment of brain tumors. In the murine brain, perivascular fibroblasts were recently identified as a novel potential constituent of the BBB. Here we present the existence of human cells that could be the equivalent to the murine brain perivascular fibroblasts. Using RNA sequencing, we show a similar transcriptomic profile of cultured human brain cells and murine perivascular fibroblasts. These data open up a window for new hypotheses on cell types involved in human CNS diseases.
脑脉管系统具有几个特定的特征，其中之一是血脑屏障（BBB），它通过允许氧气和营养物质的通过，同时防止病原体和毒素的通过，来支持和保护大脑。BBB 还防止药物有效地输送到大脑，例如用于治疗脑肿瘤。最近在鼠脑中发现了周细胞纤维母细胞作为 BBB 的一种新的潜在组成部分。在这里，我们提出了人类细胞的存在，这些细胞可能相当于鼠脑周细胞纤维母细胞。使用 RNA 测序，我们显示了培养的人脑细胞和鼠周细胞纤维母细胞的相似转录组图谱。这些数据为涉及人类中枢神经系统疾病的细胞类型的新假设开辟了一扇窗户。
