Mallmann Auriana Serra Vasconcelos, Chaves Raquell de Castro, de Oliveira Natália Ferreira, Oliveira Iris Cristina Maia, Capibaribe Victor Celso Cavalcanti, Valentim José Tiago, da Silva Daniel Moreira Alves, Sartori Danusio Pinheiro, Rodrigues Gabriel Carvalho, Filho Adriano José Maia Chaves, Riello Giovana Barbosa, Fonteles Marta Maria de França, Vasconcelos Silvânia Maria Mendes, Macedo Danielle, Gutierrez Stanley Juan Chavez, Filho José Maria Barbosa, de Carvalho Alyne Mara Rodrigues, de Sousa Francisca Cléa Florenço
Neuropsychopharmacology Laboratory, Drug Research and Development Center, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil; Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Department of Physiology and Pharmacology, Faculty of Medicine, Federal University of Ceará, Fortaleza, Ceará, Brazil.
Eur J Pharm Sci. 2021 Jul 1;162:105824. doi: 10.1016/j.ejps.2021.105824. Epub 2021 Mar 30.
Stress is crucially related to the pathophysiology of mood disorders, including depression. Since the effectiveness and number of the current pharmacological options still presents significant limitations, research on new substances is paramount. In rodents, several findings have indicated that corticosterone administration induces the manifestation of behavioral and neurochemical aspects of depression. Recently, riparin III has shown antidepressant-like properties in trials performed on animal models. Thus, our goal was to investigate the effects of riparin III on behavioral tests, monoamines levels, oxidative stress and cytokines levels in chronic corticosterone-induced model of depression. To do this, female swiss mice were treated with subcutaneous administration of corticosterone for 22 days. In addition, for the last 10 days, riparin III or fluvoxamine were also administered per os in specific test groups. Control groups received subcutaneous saline injections or distilled water per os. At the end of the timeline, the animals were killed and their hippocampi, prefrontal cortex, and striatum dissected for neurochemical analysis. Brain changes following corticosterone administration were confirmed, and riparin III could reversed the most abnormal behavioral and neurochemical corticosterone-induced alterations. These results suggest the potential antioxidant, anti-inflammatory and antidepressant effects of riparin III after a chronic stress exposure.
应激与包括抑郁症在内的情绪障碍的病理生理学密切相关。由于目前药物治疗方案的有效性和种类仍存在显著局限性，因此对新物质的研究至关重要。在啮齿动物中，多项研究结果表明，给予皮质酮会诱发抑郁症行为和神经化学方面的表现。最近，瑞帕林III在动物模型试验中显示出类抗抑郁特性。因此，我们的目标是研究瑞帕林III对慢性皮质酮诱导的抑郁症模型行为测试、单胺水平、氧化应激和细胞因子水平的影响。为此，对雌性瑞士小鼠皮下注射皮质酮，持续22天。此外，在最后10天，特定试验组经口给予瑞帕林III或氟伏沙明。对照组皮下注射生理盐水或经口给予蒸馏水。在实验结束时，处死动物并解剖其海马体、前额叶皮质和纹状体进行神经化学分析。证实了给予皮质酮后脑的变化，并且瑞帕林III可以逆转皮质酮诱导的最异常的行为和神经化学改变。这些结果表明，在慢性应激暴露后，瑞帕林III具有潜在的抗氧化、抗炎和抗抑郁作用。
