ISAL Foundation Institute for Research on Pain, Torre Pedrera, Italy.
Department of Health Science, Institute of Research for Food Safety & Health (IRC-FSH), University "Magna Graecia" of Catanzaro, Viale Europa, Loc. Germaneto, Catanzaro, Italy.
Curr Opin Pharmacol. 2021 Apr;57:184-191. doi: 10.1016/j.coph.2021.02.007. Epub 2021 Mar 30.
The worlds of chronic pain and addiction continue to intersect too often in many ways. Chronic pain significantly impairs and disrupts the quality of life of millions of people worldwide. Opioids remain the most prescribed pharmacotherapy offered to patients to alleviate chronic pain. The extensive and often unnecessary prescription of opioids has created a surge in the prevalence of opioid use disorders and opioid overdose-related deaths. In this brief review, we aim to provide a bench-to-bedside overview of promising biomarkers, therapeutic targets, and challenges related to treating patients with chronic pain. We hope this review will inspire new opportunities and insights into the development of novel, nonaddictive treatments for chronic pain that will be available to patients in the near future.
慢性疼痛和成瘾这两个领域继续以多种方式频繁交汇。慢性疼痛严重损害和扰乱了全球数以百万计的人的生活质量。阿片类药物仍然是为缓解慢性疼痛而向患者提供的最常开出的药物治疗方法。阿片类药物的广泛且往往不必要的处方导致了阿片类药物使用障碍和阿片类药物过量相关死亡的激增。在这篇简要的综述中，我们旨在提供一个从实验室到临床的概述，介绍与治疗慢性疼痛患者相关的有前途的生物标志物、治疗靶点和挑战。我们希望这篇综述将为开发新型、无成瘾性的慢性疼痛治疗方法提供新的机会和思路，这些方法将在不久的将来为患者提供。
