Heidari Mohammad Eghbal, Nadali Javad, Parouhan Ali, Azarafraz Mahdi, Tabatabai Seyed Mohamadhasan, Irvani Seyed Sina Naghibi, Eskandari Fereshte, Gharebaghi Alireza
Student 's scientific research center, Tehran University of Medical Sciences, Theran, Iran.
School of Nursing and Midwifery, Shahroud University of Medical Sciences, Shahroud, Iran.
J Affect Disord. 2021 May 15;287:182-190. doi: 10.1016/j.jad.2021.03.015. Epub 2021 Mar 12.
Amyotrophic lateral sclerosis (ALS) people have a high risk of severe mental disorders, like depression, which impacts their function, quality of life, and mobility. However, there are no estimates of depression based paper published. This study aimed conduct a systematic review and meta-analysis of the prevalence of depression in ALS patients around the world.
PubMed/Medline, Web of science, Scopus, Embase, and Ovid are searched to identify papers that reporting the prevalence of depression. Studies are included in random-effects meta-analyses of the prevalence of depression. Subgroup analyses are performed on the severity of depression, instruments of depression, type of studies, and study regions.
46 eligible studies reported prevalence of depression. The pooled prevalence of depression among ALS people was 34% (27%-41%). According to the severity of depression, mild, moderate, and severe depression were 29%, 16%, and 8%, respectively. For studies using BDI, PHQ, and HADS, the pooled prevalence of depression was 50%, 20%, and 15%, respectively.
ALS people have a high prevalence of depression. The high prevalence of depression causes a reduction of quality of life and mobility. The study identifies a population group at high risk needing special attention in clinical practice.
肌萎缩侧索硬化症（ALS）患者患严重精神障碍（如抑郁症）的风险很高，这会影响他们的功能、生活质量和活动能力。然而，目前尚无基于抑郁症的相关研究发表。本研究旨在对全球ALS患者抑郁症患病率进行系统评价和荟萃分析。
检索PubMed/Medline、科学网、Scopus、Embase和Ovid等数据库，以识别报告抑郁症患病率的文献。将这些研究纳入抑郁症患病率的随机效应荟萃分析。对抑郁症的严重程度、抑郁症评估工具、研究类型和研究地区进行亚组分析。
46项符合条件的研究报告了抑郁症的患病率。ALS患者中抑郁症的合并患病率为34%（27%-41%）。根据抑郁症的严重程度，轻度、中度和重度抑郁症的患病率分别为29%、16%和8%。对于使用贝克抑郁量表（BDI）、患者健康问卷（PHQ）和医院焦虑抑郁量表（HADS）的研究，抑郁症的合并患病率分别为50%、20%和15%。
ALS患者抑郁症患病率较高。抑郁症的高患病率导致生活质量和活动能力下降。该研究确定了一个在临床实践中需要特别关注的高危人群。
