Maher Gillian M, McCarthy Fergus P, Khashan Ali S
INFANT Research Centre, Cork, Ireland; School of Public Health, Western Gateway Building, University College Cork, Cork, Ireland.
INFANT Research Centre, Cork, Ireland; Department of Obstetrics and Gynaecology, University College Cork, Cork, Ireland.
J Affect Disord. 2021 May 15;287:222-228. doi: 10.1016/j.jad.2021.03.040. Epub 2021 Mar 19.
The aim of this study was to examine the association between hypertensive disorders of pregnancy (HDP) and behavioural outcomes in offspring at five time-points.
We used maternal-reported data from the Millennium Cohort Study. Data on HDP were collected when children were 9-months. Data on behavioural outcomes were collected at age 3, 5, 7, 11 and 14years using the Strengths and Difficulties Questionnaire (SDQ). Multivariate logistic regression analysis examined a HDP-behavioural difficulties relationship, using validated SDQ cut-off points. Multilevel models with linear splines examined the association between HDP and repeated measures of SDQ.
18,274 singleton children were included in the study at baseline, Multivariate logistic regression suggested HDP was not significantly associated with SDQ domain cut-off points at ages 3, 7 and 11years. At age 5years, HDP was associated with a 40% increased odds of behavioural difficulties based on total SDQ(≥17) (OR:1.40, 95% CI:1.03,1.91). HDP was associated with a 43% increased odds of Peer Problem difficulties at age 5 (OR:1.43, 95% CI:1.10,1.86), and a 28% increased odds of Peer Problem difficulties(≥4) at age 14 (OR:1.28, 95% CI:1.02,1.61). In the linear spline model, mean SDQ score was higher at each time-point in those exposed to HDP, although did not always reach statistical significance.
Data on different classifications of HDP were unavailable; therefore, we could not examine the effect of gestational hypertension and preeclampsia separately.
While we did not find strong evidence of associations between HDP and behavioural outcomes overall, some associations between HDP and behavioural difficulties did persist at age 5 and 14years.
本研究旨在探讨妊娠高血压疾病（HDP）与子代在五个时间点的行为结局之间的关联。
我们使用了千禧队列研究中母亲报告的数据。当孩子9个月大时收集有关HDP的数据。使用长处与困难问卷（SDQ）在孩子3岁、5岁、7岁、11岁和14岁时收集行为结局数据。多变量逻辑回归分析使用经过验证的SDQ临界点来检验HDP与行为困难之间的关系。带有线性样条的多层次模型检验了HDP与SDQ重复测量值之间的关联。
18274名单胎儿童在基线时被纳入研究，多变量逻辑回归表明，HDP与3岁、7岁和11岁时的SDQ领域临界点无显著关联。在5岁时，基于总SDQ（≥17），HDP与行为困难几率增加40%相关（比值比：1.40，95%置信区间：1.03，1.91）。HDP与5岁时同伴问题困难几率增加43%相关（比值比：1.43，95%置信区间：1.10，1.86），与14岁时同伴问题困难（≥4）几率增加28%相关（比值比：1.28，95%置信区间：1.02，1.61）。在线性样条模型中，暴露于HDP的儿童在每个时间点的平均SDQ得分均较高，尽管并非总是具有统计学意义。
无法获得关于HDP不同分类的数据；因此，我们无法分别研究妊娠期高血压和先兆子痫的影响。
虽然我们没有找到HDP与总体行为结局之间存在关联的有力证据，但HDP与行为困难之间的一些关联在5岁和14岁时确实持续存在。
