己酮可可碱对胃黏膜的保护作用。

Protective effect of pentoxifylline on gastric mucosa.

作者信息

Tominaga G, Waxman K, Soliman M H, Sarfeh I J, Bui H X, Tarnawski A

机构信息

Department of Surgery, University of California Irvine Medical Center, Orange 92668.

出版信息

J Surg Res. 1988 Jun;44(6):727-32. doi: 10.1016/0022-4804(88)90107-2.

DOI:10.1016/0022-4804(88)90107-2

PMID:3379950

Abstract

Pentoxifylline (PF) has been shown to increase tissue oxygen tension. This study was performed to determine if PF has a protective effect on the gastric mucosa against alcohol (EtOH)-induced injury. Fasted Sprague-Dawley rats were pretreated with randomized test solution (control, normal saline, or PF, 75 mg/kg) intraperitoneally (ip). At 30 min, 100% EtOH (pH 8.5) was given intragastric. At 90 min, laparotomy was performed and gastric serosal stomach surface oxygen tensions (pO2) were measured. Stomachs were excised and opened and pH was measured. Photographs were taken and sections were obtained for histologic analysis to determine mucosal injury. The PF-pretreated rats had significantly higher serosal pO2 and significantly lower intragastric pH than control animals. There was significantly less gross and histologic mucosal injury in PF-treated animals. We conclude that PF is protective against EtOH gastric mucosal injury. This effect correlates with increased gastric serosal pO2 and is likely due to improved microcirculatory blood flow following PF administration.

摘要

己酮可可碱（PF）已被证明可提高组织氧张力。本研究旨在确定PF对胃黏膜是否具有抗酒精（EtOH）诱导损伤的保护作用。将禁食的斯普拉格-道利大鼠随机腹腔注射（ip）受试溶液（对照、生理盐水或75mg/kg的PF）进行预处理。30分钟时，给予100%EtOH（pH 8.5）灌胃。90分钟时，进行剖腹手术，测量胃浆膜胃表面氧张力（pO2）。切除胃并打开，测量pH值。拍照并取组织切片进行组织学分析以确定黏膜损伤情况。与对照动物相比，PF预处理的大鼠浆膜pO2显著更高，胃内pH值显著更低。PF处理的动物肉眼可见和组织学上的黏膜损伤明显更少。我们得出结论，PF对EtOH诱导的胃黏膜损伤具有保护作用。这种作用与胃浆膜pO2升高相关，可能是由于PF给药后改善了微循环血流量。