Szczyrek Michał, Mlak Radosław, Szudy-Szczyrek Aneta, Kędziora Karolina, Małecka-Massalska Teresa, Krawczyk Paweł, Milanowski Janusz
Department of Pneumonology, Oncology and Allergology, Medical University of Lublin, 20-090 Lublin, Poland.
Department of Human Physiology, Medical University of Lublin, 20-080 Lublin, Poland.
J Clin Med. 2021 Mar 8;10(5):1126. doi: 10.3390/jcm10051126.
Caspase 8 is a protein involved in the process of cell apoptosis, which may affect the efficacy of anti-cancer treatment. The aim of our study was to determine the impact of polymorphisms in the gene encoding caspase 8 on the prognosis in non-small-cell lung cancer (NSCLC). The study involved 99 patients with newly diagnosed locally advanced or metastatic NSCLC treated with platinum-based chemotherapy. The presence of the GG genotype was associated with distant metastases, smoking, and a family history of cancer. The higher risk of early progression was associated with weight loss and the genotype (GG vs. AG or AA: 20.51% vs. 2.86%). The higher risk of progression-free survival (PFS) shortening was associated with a higher stage of disease (hazard ratio (HR) = 2.50, 95% CI: 1.61-3.89, < 0.0001), distant metastases (HR = 2.30, 95% CI: 1.42-3.72, = 0.0016), and the GG genotype (HR = 1.68, 95% CI: 1.10-2.57, = 0.0152). The influence of the GG genotype on the PFS was confirmed in a multivariate analysis (HR = 1.80, 95% CI: 1.06-3.05, = 0.0317). We did not confirm the influence of genotypes on the overall survival (OS).
半胱天冬酶8是一种参与细胞凋亡过程的蛋白质，它可能会影响抗癌治疗的疗效。我们研究的目的是确定编码半胱天冬酶8的基因多态性对非小细胞肺癌（NSCLC）预后的影响。该研究纳入了99例新诊断的局部晚期或转移性NSCLC患者，他们接受了铂类化疗。GG基因型的存在与远处转移、吸烟和癌症家族史有关。早期进展的较高风险与体重减轻和该基因型有关（GG与AG或AA相比：20.51%对2.86%）。无进展生存期（PFS）缩短的较高风险与疾病分期较高（风险比（HR）=2.50，95%置信区间：1.61-3.89，P<0.0001）、远处转移（HR = 2.30，95%置信区间：1.42-3.72，P = 0.0016）和GG基因型（HR = 1.68，95%置信区间：1.10-2.57，P = 0.0152）有关。GG基因型对PFS的影响在多变量分析中得到证实（HR = 1.80，95%置信区间：1.06-3.05，P = 0.0317）。我们未证实基因型对总生存期（OS）的影响。
