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Fc受体γ链在呼吸道合胞病毒感染异源疫苗接种后诱导保护性免疫反应中的作用

Roles of the Fc Receptor γ-Chain in Inducing Protective Immune Responses after Heterologous Vaccination against Respiratory Syncytial Virus Infection.

作者信息

Hwang Hye Suk, Lee Young-Tae, Kim Ki-Hye, Seo Ho Seong, Yang Kap Seung, Cho Hoonsung, Kang Sang-Moo

机构信息

Alan G. MacDiarmid Energy Research Institute, Chonnam National University, Gwangju 61186, Korea.

School of Materials Science & Engineering, Chonnam National University, Gwangju 61186, Korea.

出版信息

Vaccines (Basel). 2021 Mar 8;9(3):232. doi: 10.3390/vaccines9030232.

DOI:10.3390/vaccines9030232
PMID:33800349
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7998258/
Abstract

The roles of the Fc receptor (FcR) in protection or inflammatory disease after respiratory syncytial virus (RSV) vaccination and infection remain unknown. Virus-like particles containing RSV fusion proteins (RSV F-VLPs) induce T-helper type 1 antibody responses and protection against RSV. Heterologous RSV F-VLP prime and formalin-inactivated RSV (FI-RSV) boost vaccination has been reported to be effective in providing protection without inflammatory disease. Here, we investigated whether the FcRγ-chain is important for immune protection by the heterologous F-VLP and FI-RSV vaccination using FcRγ-chain knockout (-/-) mice. RSV F-VLP-primed and FI-RSV-boosted FcRγ -/- mice displayed less protective efficacy, as shown by higher lung viral titers upon RSV challenge, compared to RSV F-VLP-primed and FI-RSV-boosted immunized wild-type mice. RSV F-VLP and FI-RSV immunization induced lower levels of neutralizing activity and interferon-γ-producing CD8 T-cells in the bronchoalveolar lavage cells of FcRγ -/- mice than in those of wild-type mice. In addition, FcRγ -/- mice displayed a trend of enhancing lung histopathology after RSV vaccination and infection. This study suggests that the FcRγ-chain plays an important role in inducing antiviral protection and CD8 T-cell responses in RSV F-VLP prime and FI-RSV boost vaccination after RSV infections.

摘要

呼吸道合胞病毒（RSV）疫苗接种和感染后，Fc受体（FcR）在保护或炎症性疾病中的作用尚不清楚。含有RSV融合蛋白的病毒样颗粒（RSV F-VLPs）可诱导1型辅助性T细胞抗体反应并提供针对RSV的保护。据报道，异源RSV F-VLP初免和福尔马林灭活RSV（FI-RSV）加强免疫接种在提供保护而无炎症性疾病方面是有效的。在此，我们使用FcRγ链敲除（-/-）小鼠研究了FcRγ链对于异源F-VLP和FI-RSV疫苗接种诱导的免疫保护是否重要。与RSV F-VLP初免和FI-RSV加强免疫的野生型小鼠相比，RSV F-VLP初免和FI-RSV加强免疫的FcRγ -/-小鼠在RSV攻击后肺病毒滴度更高，显示出较低的保护效力。与野生型小鼠相比，RSV F-VLP和FI-RSV免疫在FcRγ -/-小鼠的支气管肺泡灌洗细胞中诱导产生的中和活性水平和产生干扰素-γ的CD8 T细胞水平更低。此外，FcRγ -/-小鼠在RSV疫苗接种和感染后呈现出肺部组织病理学加重的趋势。这项研究表明，FcRγ链在RSV感染后RSV F-VLP初免和FI-RSV加强免疫接种诱导抗病毒保护和CD8 T细胞反应中起重要作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7080/7998258/0d1a51a05771/vaccines-09-00232-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7080/7998258/2081b9455d92/vaccines-09-00232-g001.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7080/7998258/6dcbce4dfe35/vaccines-09-00232-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7080/7998258/50a0291b9778/vaccines-09-00232-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7080/7998258/cf75c7145e1b/vaccines-09-00232-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7080/7998258/0d1a51a05771/vaccines-09-00232-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7080/7998258/2081b9455d92/vaccines-09-00232-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7080/7998258/d221dd85cbd8/vaccines-09-00232-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7080/7998258/6dcbce4dfe35/vaccines-09-00232-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7080/7998258/50a0291b9778/vaccines-09-00232-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7080/7998258/cf75c7145e1b/vaccines-09-00232-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7080/7998258/0d1a51a05771/vaccines-09-00232-g006.jpg

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本文引用的文献

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