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新型噻二唑基氨基甲酸盐 3-((5-(三氟甲基)-1,3,4-噻二唑-2-基)氨基)苯并[1,2,5]噻二唑 1,1-二氧化物作为镉的选择性螯合剂的发展：合成、结构和螯合性能

On the Development of Selective Chelators for Cadmium: Synthesis, Structure and Chelating Properties of 3-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)benzo[]isothiazole 1,1-dioxide, a Novel Thiadiazolyl Saccharinate.

机构信息

Center of Marine Sciences, CCMAR, Gambelas Campus, University of Algarve, UAlg, 8005-139 Faro, Portugal.

Department of Chemistry and Pharmacy, Faculty of Sciences and Technology, FCT, Gambelas Campus, University of Algarve, UAlg, 8005-139 Faro, Portugal.

出版信息

Molecules. 2021 Mar 10;26(6):1501. doi: 10.3390/molecules26061501.

DOI:10.3390/molecules26061501
PMID:33801902
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7999908/
Abstract

Aquatic contamination by heavy metals is a major concern for the serious negative consequences it has for plants, animals, and humans. Among the most toxic metals, Cd(II) stands out since selective and truly efficient methodologies for its removal are not known. We report a novel multidentate chelating agent comprising the heterocycles thiadiazole and benzisothiazole. 3-((5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl)amino)benzo[]isothiazole 1,1-dioxide (AL14) was synthesized from cheap saccharin and characterized by different techniques, including single crystal X-ray crystallography. Our studies revealed the efficiency and selectivity of AL14 for the chelation of dissolved Cd(II) (as compared to Cu(II) and Fe(II)). Different spectral changes were observed upon the addition of Cd(II) and Cu(II) during UV-Vis titrations, suggesting different complexation interactions with both metals.

摘要

重金属对水生生物的污染是一个主要关注点，因为它会对植物、动物和人类产生严重的负面影响。在最具毒性的金属中，Cd(II)尤为突出，因为目前还没有针对其去除的选择性和真正有效的方法。我们报告了一种新型的多齿螯合剂，它由噻二唑和苯并异噻唑杂环组成。3-((5-(三氟甲基)-1,3,4-噻二唑-2-基)氨基)苯并[1,2-d]异噻唑 1,1-二氧化物（AL14）由廉价的糖精合成，并通过多种技术进行了表征，包括单晶 X 射线晶体学。我们的研究表明，AL14 对溶解的 Cd(II)（与 Cu(II)和 Fe(II)相比）具有高效性和选择性。在紫外-可见滴定过程中，当加入 Cd(II)和 Cu(II)时，观察到不同的光谱变化，这表明与这两种金属的络合相互作用不同。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da18/7999908/0235136e5645/molecules-26-01501-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da18/7999908/d950cd875923/molecules-26-01501-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da18/7999908/32bdd21a05f3/molecules-26-01501-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da18/7999908/9408c17def97/molecules-26-01501-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da18/7999908/a83ad6592ef2/molecules-26-01501-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da18/7999908/280a08967ed8/molecules-26-01501-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da18/7999908/0235136e5645/molecules-26-01501-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da18/7999908/d950cd875923/molecules-26-01501-sch001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da18/7999908/32bdd21a05f3/molecules-26-01501-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da18/7999908/9408c17def97/molecules-26-01501-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da18/7999908/a83ad6592ef2/molecules-26-01501-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da18/7999908/280a08967ed8/molecules-26-01501-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/da18/7999908/0235136e5645/molecules-26-01501-g005.jpg

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