Oniani T N, Lortkipanidze N D, Maĭsuradze L M, Oniani L T
Neirofiziologiia. 1988;20(1):20-8.
Neurophysiological analysis of the effects of selective and total paradoxical sleep deprivation (PSD) involving the replacement of paradoxical sleep (PS) phases by equivalent (as to duration) episodes of wakefulness is carried out. In contrast to the "classical" method of momentary awakening of the animal, a new method does not lead to: (1) the accumulation of PS need associated with more frequent PS onsets during deprivation; (2) PS rebound in a postdeprivation period; (3) dissociation of PS components, i.e. their occasional occurrence in other phases of the sleep-wakefulness cycle due to the phenomenon of self-deprivation; (4) increase in the rate of pontogeniculo-occipital (PGO) spikes, eye movements and heart rate during PS phases in the postdeprivation period. The application of selective and total PSD techniques caused no noticeable changes in the functional state and integrative activity of the brain, the latter warranting its successful use for treatment of some psychoneurological disturbances in clinics. The assumption has been advanced about the similarity of the neurochemical changes forming the need both for wakefulness and PS.
开展了对选择性和完全异相睡眠剥夺（PSD）影响的神经生理学分析，其中通过等效（时长）的清醒时段替代异相睡眠（PS）阶段。与动物瞬间觉醒的“经典”方法不同，新方法不会导致：（1）与剥夺期间更频繁的PS发作相关的PS需求积累；（2）剥夺后阶段的PS反弹；（3）PS成分的解离，即由于自我剥夺现象，它们偶尔出现在睡眠 - 觉醒周期的其他阶段；（4）剥夺后阶段PS期间脑桥 - 膝状体 - 枕叶（PGO）尖峰、眼球运动和心率的增加。选择性和完全PSD技术的应用在大脑的功能状态和整合活动方面未引起明显变化，后者保证了其在临床治疗某些精神神经障碍方面的成功应用。关于形成清醒和PS需求的神经化学变化相似性的假设已经提出。
